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osteogenic differentiation

Bone Morphogenetic Protein 9 Enhances Osteogenic and Angiogenic Responses of Human Amniotic Mesenchymal Stem Cells Cocultured with Umbilical Vein Endothelial Cells through the PI3K/AKT/M-TOR...

[Aging] The authors investigated the effects of bone morphogenetic protein 9 on osteogenesis and angiogenesis of human amniotic mesenchymal stem cells (hAMSCs) cocultured with human umbilical vein endothelial cells (HUVECs) and determined the possible underlying molecular mechanism.

Comprehensive Analysis of Human Chorionic Membrane Extracts Regulating Mesenchymal Stem Cells during Osteogenesis

[Cell Proliferation] Researchers showed the in vitro and in vivo bone-forming ability of chorionic membrane extract (CME) using human osteoblasts and bone defect animal models, suggesting that CME greatly enhanced osteogenesis by providing an osteoconductive environment for the osteogenesis of osteoblasts.

Three-Dimensional Printing of Bioceramic-Induced Macrophage Exosomes: Immunomodulation and Osteogenesis/Angiogenesis

[NPG Asia Materials] 3D printed macrophage exosomes scaffolds, exhibiting a predefined structure and persistent release of exosomes, displayed distinct immunomodulatory effects and improved osteogenesis/angiogenesis.

The m6A “Reader” YTHDF1 Promotes Osteogenesis of Bone Marrow Mesenchymal Stem Cells through Translational Control of ZNF839

[Cell Death & Disease] To identify the possible role of m6A binding protein YTHDF1 in human bone marrow MSCs osteogenesis in vivo, investigators constructed Ythdf1 knockout mice and showed that depletion of Ythdf1 would result in decreased bone mass in vivo.

Bone Regeneration in Rat Calvarial Defects Using Dissociated or Spheroid Mesenchymal Stromal Cells in Scaffold-Hydrogel Constructs

[Stem Cell Research & Therapy] Investigators compared the potential of human bone marrow MSCs cultured as 2D monolayers or 3D spheroids encapsulated in constructs of 3D-printed poly-L-lactide-co-trimethylene carbonate scaffolds and modified human platelet lysate hydrogels for bone regeneration.

TGF-Beta Pathway Inhibition as the Therapeutic Acceleration of Diabetic Bone Regeneration

[Journal of Orthopaedic Research] Scientists investigated the gene expression profile of bones from type 2 diabetic mice and wild-type mice by comparative microarray analysis before and after placing tibial defects and examined the expression of several osteogenesis- and osteoclastogenesis-related markers by quantitative real-time polymerase chain reaction.

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