osteogenic differentiation

[Stem Cell Research & Therapy] Investigators explored the effects of PPARβ/δ agonist on the regeneration of diabetic bone defects and the osteogenic differentiation of rat bone marrow MSCs under a pathological high-glucose condition.

[Bioengineered] Researchers demonstrated that exosomes extracted from bone marrow MSCs (BMSC-exo) significantly promoted HFOB1.19 differentiation to osteoblasts, and found that BMSC-exo were enriched with miR-196a and delivered miR-196a to HFOB1.19 cells to inhibit its target Dkk1, which was a negative regulator of Wnt/β-catenin pathway.

[Cellular Reprogramming] MSCs were extracted from adipose, umbilical cord, and placental tissues. The expression levels of 80 cytokines were detected, and the data demonstrated that the three MSC types abundantly secreted insulin-like growth factor-binding protein (IGFBP)-4, IGFBP-3, tissue inhibitor of metalloproteinase (TIMP)-1, TIMP-2, IGFBP-6, monocyte chemoattractant protein-1, and granulocyte colony-stimulating factor.

[Journal of Cellular Physiology] Investigators assessed the Mucin 1-mediated effect of hypoxia on the proteomic composition of human osteoblast-derived extracellular matrices (ECM) and characterized their osteogenic and angiogenic potentials in the produced ECMs.

[Scientific Reports] Investigators analyzed RNA-sequence data to reveal expression profiles of circRNAs during osteogenesis of human umbilical cord MSCs, then elucidated the underlying mechanisms of action.

[Stem Cells and Development] Investigators found that TNF-α could upregulate inflammatory cytokines, Il-6, Mmp-9, and Il-1β, and establish an inflammatory environment.