osteogenic differentiation

[Journal of Dental Research] The authors proposed to infuse a degradable RGD-functionalized alginate matrix with osteoid-like stiffness, as an artificial ECM, to a rigid 3D-printed hydroxyapatite scaffold for maxillofacial regeneration.

[Scientific Reports] The authors set up a new natural scaffold deriving from a decellularized porcine mucoperiosteum, engineered by an innovative micro-perforation procedure based on Quantum Molecular Resonance and then subjected to in vitro recellularization with human bone marrow-derived mesenchymal stem cells.

[Cell Reports] Researchers identified a periosteal-osteoblast-derived secretory peptide, Osteocrin, as a mechanotransducer involved in load-induced long bone growth.

[Stem Cell Reports] Scientists used Costello syndrome induced pluripotent stem cells (iPSCs) undergoing osteogenic differentiation to investigate how dysregulation of extracellular matrix (ECM) remodeling proteins contributed to impaired osteogenesis.

[Biomaterials Science] Through in vitro tests, scientists found that copper-doped bioactive glass enhanced angiogenesis by activating the pro-inflammatory environment and the HIF-1α pathway of human umbilical vein endothelial cells.

[Molecular Therapy-Nucleic Acids] Investigators explored the relationships among osteoblast differentiation, N-acetyltransferase 10 (NAT10) , and N4-acetylcytidine (ac4C) and found that NAT0 expression and the ac4C level of total RNA were decreased in the bone tissues of OVX mice and osteoporosis patients.