Tideglusib Suppresses Stem-Cell-Like Features and Progression of Osteosarcoma by Inhibiting GSK-3β/NOTCH1 Signaling

The authors found that tideglusib (TID) markedly reduced the cell viability of different osteosarcoma cell lines. Cell cycle arrest distributed in G2/M was markedly up-regulated in TID-incubated osteosarcoma cells through enhancing p21 expression levels.
[Biochemical and Biophysical Research Communications]
Wei, D., Zhu, X., Li, S., Liu, G., Wang, Y., Wang, W., Zhang, Q., & Jiang, S. (2021). Tideglusib suppresses stem-cell-like features and progression of osteosarcoma by inhibiting GSK-3β/NOTCH1 signaling. Biochemical and Biophysical Research Communications, 554, 206–213. https://doi.org/10.1016/j.bbrc.2020.12.055 Cite
Abstract
Bookmark

No account yet? Register

0
Share

Metabolic Compensation Activates Pro-Survival mTORC1 Signaling Upon 3-Phosphoglycerate Dehydrogenase Inhibition in Osteosarcoma

The rate-limiting enzyme in the biosynthesis of serine from glucose, 3-phosphoglycerate dehydrogenase (PHGDH), was examined, and an inverse correlation between PHGDH expression and relapse-free and overall survival in osteosarcoma patients was found.
[Cell Reports]
Rathore, R., Caldwell, K. E., Schutt, C., Brashears, C. B., Prudner, B. C., Ehrhardt, W. R., Leung, C. H., Lin, H., Daw, N. C., Beird, H. C., Giles, A., Wang, W.-L., Lazar, A. J., Chrisinger, J. S. A., Livingston, J. A., & Tine, B. A. V. (2021). Metabolic compensation activates pro-survival mTORC1 signaling upon 3-phosphoglycerate dehydrogenase inhibition in osteosarcoma. Cell Reports, 34(4). https://doi.org/10.1016/j.celrep.2020.108678 Cite
Full ArticleGraphical Abstract
Bookmark

No account yet? Register

0
Share

ALKBH5 Suppresses Tumor Progression via an m6A-Dependent Epigenetic Silencing of Pre-miR-181b-1/Yap Signaling Axis in Osteosarcoma

The authors explored the potential involvement of ALKBH5 in osteosarcoma and deciphered the underlying cellular/molecular mechanisms. They discovered downregulated levels of demethylase ALKBH5 were correlated with increased m6A methylation in osteosarcoma cells/tissues compared with normal osteoblasts cells/tissues.
[Cell Death & Disease]
Yuan, Y., Yan, G., He, M., Lei, H., Li, L., Wang, Y., He, X., Li, G., Wang, Q., Gao, Y., Qu, Z., Mei, Z., Shen, Z., Pu, J., Wang, A., Zhao, W., Jiang, H., Du, W., & Yang, L. (2021). ALKBH5 suppresses tumor progression via an m 6 A-dependent epigenetic silencing of pre-miR-181b-1/YAP signaling axis in osteosarcoma. Cell Death & Disease, 12(1), 1–16. https://doi.org/10.1038/s41419-020-03315-x Cite
Full Article
Bookmark

No account yet? Register

0
Share

Nanoparticle Enhanced Combination Therapy for Stem-Like Progenitors Defined by Single-Cell Transcriptomics in Chemotherapy-Resistant Osteosarcoma

Scientists utilized single-cell transcriptomics to systematically map the cell-type-specific gene expression in a chemotherapy-resistant osteosarcoma tumor.
[Signal Transduction and Targeted Therapy]
Wang, L., Huang, X., You, X., Yi, T., Lu, B., Liu, J., Lu, G., Ma, M., Zou, C., Wu, J., & Zhao, W. (2020). Nanoparticle enhanced combination therapy for stem-like progenitors defined by single-cell transcriptomics in chemotherapy-resistant osteosarcoma. Signal Transduction and Targeted Therapy, 5(1), 1–13. https://doi.org/10.1038/s41392-020-00248-x Cite
Full Article
Bookmark

No account yet? Register

0
Share

Chitinase-3 Like-Protein-1 Function and Its Role in Diseases

Non-enzymatic chitinase-3 like-protein-1 (CHI3L1) binds to chitin, heparin, and hyaluronic acid, and is regulated by ECM changes, cytokines, growth factors, drugs, and stress. This review summarizes the potential roles and mechanisms of CHI3L1 in oncogenesis and disease pathogenesis, then posits investigational strategies for targeted therapies.
[Signal Transduction and Targeted Therapy]
Zhao, T., Su, Z., Li, Y., Zhang, X., & You, Q. (2020). Chitinase-3 like-protein-1 function and its role in diseases. Signal Transduction and Targeted Therapy, 5(1), 1–20. https://doi.org/10.1038/s41392-020-00303-7 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Development of an Artificial Antibody Specific for HLA/Peptide Complex Derived from Cancer Stem-Like Cell/Cancer-Initiating Cell Antigen DNAJB8

Investigators developed a therapeutic single-chain variable-fragment antibody that recognises the cancer stem-like cell/cancer-initiating cell antigen, DNAJB8.
[British Journal of Cancer]
Abstract
Bookmark

No account yet? Register

0
Share

Role of HSP70 in Response to (Thermo)Radiotherapy: Analysis of Gene Expression in Canine Osteosarcoma Cells by RNA-seq

Researchers investigated up- and down-regulated genes in response to (thermo)radiotherapy in HSP70 proficient and deficient canine osteosarcoma cell line, and functional role of HSP70 in the mechanism of thermoradiosensitization.
[Scientific Reports]
Full Article
Bookmark

No account yet? Register

0
Share
Share