Chitinase-3 Like-Protein-1 Function and Its Role in Diseases

Non-enzymatic chitinase-3 like-protein-1 (CHI3L1) binds to chitin, heparin, and hyaluronic acid, and is regulated by ECM changes, cytokines, growth factors, drugs, and stress. This review summarizes the potential roles and mechanisms of CHI3L1 in oncogenesis and disease pathogenesis, then posits investigational strategies for targeted therapies.
[Signal Transduction and Targeted Therapy]
Zhao, T., Su, Z., Li, Y., Zhang, X., & You, Q. (2020). Chitinase-3 like-protein-1 function and its role in diseases. Signal Transduction and Targeted Therapy, 5(1), 1–20. https://doi.org/10.1038/s41392-020-00303-7 Cite
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Development of an Artificial Antibody Specific for HLA/Peptide Complex Derived from Cancer Stem-Like Cell/Cancer-Initiating Cell Antigen DNAJB8

Investigators developed a therapeutic single-chain variable-fragment antibody that recognises the cancer stem-like cell/cancer-initiating cell antigen, DNAJB8.
[British Journal of Cancer]
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Role of HSP70 in Response to (Thermo)Radiotherapy: Analysis of Gene Expression in Canine Osteosarcoma Cells by RNA-seq

Researchers investigated up- and down-regulated genes in response to (thermo)radiotherapy in HSP70 proficient and deficient canine osteosarcoma cell line, and functional role of HSP70 in the mechanism of thermoradiosensitization.
[Scientific Reports]
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