Chitinase-3 Like-Protein-1 Function and Its Role in Diseases

Non-enzymatic chitinase-3 like-protein-1 (CHI3L1) binds to chitin, heparin, and hyaluronic acid, and is regulated by ECM changes, cytokines, growth factors, drugs, and stress. This review summarizes the potential roles and mechanisms of CHI3L1 in oncogenesis and disease pathogenesis, then posits investigational strategies for targeted therapies.
[Signal Transduction and Targeted Therapy]
Zhao, T., Su, Z., Li, Y., Zhang, X., & You, Q. (2020). Chitinase-3 like-protein-1 function and its role in diseases. Signal Transduction and Targeted Therapy, 5(1), 1–20. https://doi.org/10.1038/s41392-020-00303-7 Cite
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Chimeric Antigen Receptor-Modified T Cells Targeting EphA2 for the Immunotherapy of Pediatric Bone Tumors

Investigators tested human erythropoietin-producing hepatocellular receptor tyrosine kinase class A2 directed CAR T cells for their capacity to target and kill human paediatric osteosarcoma and Ewing sarcoma tumour cells using in vitro and in vivo assays.
[Cancer Gene Therapy]
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WTAP Promotes Osteosarcoma Tumorigenesis by Repressing HMBOX1 Expression in an m6A-Dependent Manner

WTAP was found to be highly expressed in osteosarcoma tissue and it was an independent prognostic factor for overall survival in osteosarcoma.
[Cell Death & Disease]
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Development of an Artificial Antibody Specific for HLA/Peptide Complex Derived from Cancer Stem-Like Cell/Cancer-Initiating Cell Antigen DNAJB8

Investigators developed a therapeutic single-chain variable-fragment antibody that recognises the cancer stem-like cell/cancer-initiating cell antigen, DNAJB8.
[British Journal of Cancer]
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Role of HSP70 in Response to (Thermo)Radiotherapy: Analysis of Gene Expression in Canine Osteosarcoma Cells by RNA-seq

Researchers investigated up- and down-regulated genes in response to (thermo)radiotherapy in HSP70 proficient and deficient canine osteosarcoma cell line, and functional role of HSP70 in the mechanism of thermoradiosensitization.
[Scientific Reports]
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