osteosarcoma

[Cell Death & Disease] Investigators found that N-(3-aminopropyl)-2-[(3-methylphenyl) methoxy]-N-(2-thienylmethyl) benzamide hydrochloride (AMTB) suppressed osteosarcoma cell proliferation, metastasis and induced cellular apoptosis.

[Aging] Scientists identified that the treatment of levobupivacaine suppressed proliferation of osteosarcoma cells in vitro.

[Cell Death & Disease] Scientists investigated the therapeutic potential of bevacizumab in angiogenesis during osteosarcoma and the related mechanisms.

[Laboratory Investigation] Investigators explored the role of non-coding RNA activated by DNA damage (NORAD) derived from extracellular vesicles of bone MSCs in osteosarcoma.

[Cell Death Discovery] Scientists found that the expression of the c-Myc oncogene was negatively correlated with T cell infiltration rate in osteosarcoma. Pharmacological inhibition of c-Myc with JQ-1 significantly reduced tumor burden and improved overall survival in an immunocompetent syngeneic murine model of osteosarcoma.

[British Journal of Cancer] The authors indicated that administration of A vivo morpholino with or without chemotherapeutics could substantially improve osteosarcoma (OS) outcome with respect to tumor expansion and osteolytic corruption of bone in experimental OS model.