The authors found that tideglusib (TID) markedly reduced the cell viability of different osteosarcoma cell lines. Cell cycle arrest distributed in G2/M was markedly up-regulated in TID-incubated osteosarcoma cells through enhancing p21 expression levels.
[Biochemical and Biophysical Research Communications]
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Wei, D., Zhu, X., Li, S., Liu, G., Wang, Y., Wang, W., Zhang, Q., & Jiang, S. (2021). Tideglusib suppresses stem-cell-like features and progression of osteosarcoma by inhibiting GSK-3β/NOTCH1 signaling. Biochemical and Biophysical Research Communications, 554, 206–213. https://doi.org/10.1016/j.bbrc.2020.12.055 Cite
Scientists present the recent developments in bifunctional biomaterials to achieve a new strategy for bone tumor therapy. The selected bifunctional materials include 3D-printed scaffolds, nano/microparticle-containing scaffolds, hydrogels, and bone-targeting nanomaterials.
The authors found high expression of miR-151-3p in osteosarcoma tissues, and miR-151-3p derived from cancer associated fribroblast-extracellular vesicles promoted the process of epithelial–mesenchymal transition, migration, and invasion of MG63 cells.
[Cancer Gene Therapy]
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Wang, P., Wang, C., Zhu, L., Li, P., Tang, X., Wang, J., Hu, F., Qiao, G., Xie, C., & Zhu, C. (2021). MiR-151-3p transferred by cancer-associated fibroblast-derived extracellular vesicles promotes osteosarcoma progression through the CHL1/integrin 1β/TGF-β axis. Cancer Gene Therapy, 1–15. https://doi.org/10.1038/s41417-021-00304-w Cite
Researchers report the unexpected finding that median expression of stearoyl CoA desaturase is low in glioblastoma relative to normal brain due to hypermethylation and unintentional monoallelic co-deletion with phosphatase and tensin homolog in a subset of patients.
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Oatman, N., Dasgupta, N., Arora, P., Choi, K., Gawali, M. V., Gupta, N., Parameswaran, S., Salomone, J., Reisz, J. A., Lawler, S., Furnari, F., Brennan, C., Wu, J., Sallans, L., Gudelsky, G., Desai, P., Gebelein, B., Weirauch, M. T., D’Alessandro, A., … Dasgupta, B. (2021). Mechanisms of stearoyl CoA desaturase inhibitor sensitivity and acquired resistance in cancer. Science Advances, 7(7), eabd7459. https://doi.org/10.1126/sciadv.abd7459 Cite
The rate-limiting enzyme in the biosynthesis of serine from glucose, 3-phosphoglycerate dehydrogenase (PHGDH), was examined, and an inverse correlation between PHGDH expression and relapse-free and overall survival in osteosarcoma patients was found.
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Rathore, R., Caldwell, K. E., Schutt, C., Brashears, C. B., Prudner, B. C., Ehrhardt, W. R., Leung, C. H., Lin, H., Daw, N. C., Beird, H. C., Giles, A., Wang, W.-L., Lazar, A. J., Chrisinger, J. S. A., Livingston, J. A., & Tine, B. A. V. (2021). Metabolic compensation activates pro-survival mTORC1 signaling upon 3-phosphoglycerate dehydrogenase inhibition in osteosarcoma. Cell Reports, 34(4). https://doi.org/10.1016/j.celrep.2020.108678 Cite
Investigators identified a prominent FBJ osteosarcoma oncogene mRNA and protein signature in recently activated satellite cells that was rapidly, heterogeneously, and transiently induced by muscle damage.
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Osteosarcoma (OS) is the most common malignant bone tumor in children and young adults. Despite high-risk factors being identified, no test for early detection is available. This study aimed to identify circulating nucleic acid sequences associated with serum extracellular vesicle preparations at the time of OS diagnosis, as a step towards an OS early detection assay.
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The authors explored the potential involvement of ALKBH5 in osteosarcoma and deciphered the underlying cellular/molecular mechanisms. They discovered downregulated levels of demethylase ALKBH5 were correlated with increased m6A methylation in osteosarcoma cells/tissues compared with normal osteoblasts cells/tissues.
[Cell Death & Disease]
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Yuan, Y., Yan, G., He, M., Lei, H., Li, L., Wang, Y., He, X., Li, G., Wang, Q., Gao, Y., Qu, Z., Mei, Z., Shen, Z., Pu, J., Wang, A., Zhao, W., Jiang, H., Du, W., & Yang, L. (2021). ALKBH5 suppresses tumor progression via an m 6 A-dependent epigenetic silencing of pre-miR-181b-1/YAP signaling axis in osteosarcoma. Cell Death & Disease, 12(1), 1–16. https://doi.org/10.1038/s41419-020-03315-x Cite
To identify key drivers of metastasis, scientists studied human CCH-OS-D osteocarcinoma cells within a previously described rat acellular lung model that preserved the native lung architecture, extracellular matrix, and capillary network.
[Cancer Gene Therapy]
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Lamhamedi-Cherradi, S.-E., Mohiuddin, S., Mishra, D. K., Krishnan, S., Velasco, A. R., Vetter, A. M., Pence, K., McCall, D., Truong, D. D., Cuglievan, B., Menegaz, B. A., Utama, B., Daw, N. C., Molina, E. R., Zielinski, R. J., Livingston, J. A., Gorlick, R., Mikos, A. G., Kim, M. P., & Ludwig, J. A. (2021). Transcriptional activators YAP/TAZ and AXL orchestrate dedifferentiation, cell fate, and metastasis in human osteosarcoma. Cancer Gene Therapy, 1–14. https://doi.org/10.1038/s41417-020-00281-6 Cite
The authors outline the role of LOX-1 in tumor spreading and metastasis, evidencing its function in VEGF induction, HIF-1alpha activation, and MMP-9/MMP-2 expression, pushing up the neoangiogenic and the epithelial-mesenchymal transition process in glioblastoma, osteosarcoma, prostate, colon, breast, lung, and pancreatic tumors.
[Cancer Gene Therapy]
The authors evaluated 4‐Methoxydalbergione (4MOD) anti-astroglioma effects on both in vitro and in vivo models. In cultured astroglioma U87 cells, 4MOD inhibited cell proliferation and induced cell apoptosis in a time- and concentration-dependent manner.
[Acta Pharmacologica Sinica]
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