Tideglusib Suppresses Stem-Cell-Like Features and Progression of Osteosarcoma by Inhibiting GSK-3β/NOTCH1 Signaling

The authors found that tideglusib (TID) markedly reduced the cell viability of different osteosarcoma cell lines. Cell cycle arrest distributed in G2/M was markedly up-regulated in TID-incubated osteosarcoma cells through enhancing p21 expression levels.
[Biochemical and Biophysical Research Communications]
Wei, D., Zhu, X., Li, S., Liu, G., Wang, Y., Wang, W., Zhang, Q., & Jiang, S. (2021). Tideglusib suppresses stem-cell-like features and progression of osteosarcoma by inhibiting GSK-3β/NOTCH1 signaling. Biochemical and Biophysical Research Communications, 554, 206–213. https://doi.org/10.1016/j.bbrc.2020.12.055 Cite
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Review of a New Bone Tumor Therapy Strategy Based on Bifunctional Biomaterials

Scientists present the recent developments in bifunctional biomaterials to achieve a new strategy for bone tumor therapy. The selected bifunctional materials include 3D-printed scaffolds, nano/microparticle-containing scaffolds, hydrogels, and bone-targeting nanomaterials.
[Bone Research]
Liao, J., Han, R., Wu, Y., & Qian, Z. (2021). Review of a new bone tumor therapy strategy based on bifunctional biomaterials. Bone Research, 9(1), 1–13. https://doi.org/10.1038/s41413-021-00139-z Cite
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MiR-151-3p Transferred by Cancer-Associated Fibroblast-Derived Extracellular Vesicles Promotes Osteosarcoma Progression through the CHL1/Integrin 1β/TGF-β Axis

The authors found high expression of miR-151-3p in osteosarcoma tissues, and miR-151-3p derived from cancer associated fribroblast-extracellular vesicles promoted the process of epithelial–mesenchymal transition, migration, and invasion of MG63 cells.
[Cancer Gene Therapy]
Wang, P., Wang, C., Zhu, L., Li, P., Tang, X., Wang, J., Hu, F., Qiao, G., Xie, C., & Zhu, C. (2021). MiR-151-3p transferred by cancer-associated fibroblast-derived extracellular vesicles promotes osteosarcoma progression through the CHL1/integrin 1β/TGF-β axis. Cancer Gene Therapy, 1–15. https://doi.org/10.1038/s41417-021-00304-w Cite
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Mechanisms of Stearoyl CoA Desaturase Inhibitor Sensitivity and Acquired Resistance in Cancer

Researchers report the unexpected finding that median expression of stearoyl CoA desaturase is low in glioblastoma relative to normal brain due to hypermethylation and unintentional monoallelic co-deletion with phosphatase and tensin homolog in a subset of patients.
[Science Advances]
Oatman, N., Dasgupta, N., Arora, P., Choi, K., Gawali, M. V., Gupta, N., Parameswaran, S., Salomone, J., Reisz, J. A., Lawler, S., Furnari, F., Brennan, C., Wu, J., Sallans, L., Gudelsky, G., Desai, P., Gebelein, B., Weirauch, M. T., D’Alessandro, A., … Dasgupta, B. (2021). Mechanisms of stearoyl CoA desaturase inhibitor sensitivity and acquired resistance in cancer. Science Advances, 7(7), eabd7459. https://doi.org/10.1126/sciadv.abd7459 Cite
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Metabolic Compensation Activates Pro-Survival mTORC1 Signaling Upon 3-Phosphoglycerate Dehydrogenase Inhibition in Osteosarcoma

The rate-limiting enzyme in the biosynthesis of serine from glucose, 3-phosphoglycerate dehydrogenase (PHGDH), was examined, and an inverse correlation between PHGDH expression and relapse-free and overall survival in osteosarcoma patients was found.
[Cell Reports]
Rathore, R., Caldwell, K. E., Schutt, C., Brashears, C. B., Prudner, B. C., Ehrhardt, W. R., Leung, C. H., Lin, H., Daw, N. C., Beird, H. C., Giles, A., Wang, W.-L., Lazar, A. J., Chrisinger, J. S. A., Livingston, J. A., & Tine, B. A. V. (2021). Metabolic compensation activates pro-survival mTORC1 signaling upon 3-phosphoglycerate dehydrogenase inhibition in osteosarcoma. Cell Reports, 34(4). https://doi.org/10.1016/j.celrep.2020.108678 Cite
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FOS Licenses Early Events in Stem Cell Activation Driving Skeletal Muscle Regeneration

Investigators identified a prominent FBJ osteosarcoma oncogene mRNA and protein signature in recently activated satellite cells that was rapidly, heterogeneously, and transiently induced by muscle damage.
[Cell Reports]
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Extracellular Vesicle-Associated Repetitive Element DNAs As Candidate Osteosarcoma Biomarkers

Osteosarcoma (OS) is the most common malignant bone tumor in children and young adults. Despite high-risk factors being identified, no test for early detection is available. This study aimed to identify circulating nucleic acid sequences associated with serum extracellular vesicle preparations at the time of OS diagnosis, as a step towards an OS early detection assay.
[Scientific Reports]
Cambier, L., Stachelek, K., Triska, M., Jubran, R., Huang, M., Li, W., Zhang, J., Li, J., & Cobrinik, D. (2021). Extracellular vesicle-associated repetitive element DNAs as candidate osteosarcoma biomarkers. Scientific Reports, 11(1), 94. https://doi.org/10.1038/s41598-020-77398-z Cite
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ALKBH5 Suppresses Tumor Progression via an m6A-Dependent Epigenetic Silencing of Pre-miR-181b-1/Yap Signaling Axis in Osteosarcoma

The authors explored the potential involvement of ALKBH5 in osteosarcoma and deciphered the underlying cellular/molecular mechanisms. They discovered downregulated levels of demethylase ALKBH5 were correlated with increased m6A methylation in osteosarcoma cells/tissues compared with normal osteoblasts cells/tissues.
[Cell Death & Disease]
Yuan, Y., Yan, G., He, M., Lei, H., Li, L., Wang, Y., He, X., Li, G., Wang, Q., Gao, Y., Qu, Z., Mei, Z., Shen, Z., Pu, J., Wang, A., Zhao, W., Jiang, H., Du, W., & Yang, L. (2021). ALKBH5 suppresses tumor progression via an m 6 A-dependent epigenetic silencing of pre-miR-181b-1/YAP signaling axis in osteosarcoma. Cell Death & Disease, 12(1), 1–16. https://doi.org/10.1038/s41419-020-03315-x Cite
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Transcriptional Activators YAP/TAZ and AXL Orchestrate Dedifferentiation, Cell Fate, and Metastasis in Human Osteosarcoma

To identify key drivers of metastasis, scientists studied human CCH-OS-D osteocarcinoma cells within a previously described rat acellular lung model that preserved the native lung architecture, extracellular matrix, and capillary network.
[Cancer Gene Therapy]
Lamhamedi-Cherradi, S.-E., Mohiuddin, S., Mishra, D. K., Krishnan, S., Velasco, A. R., Vetter, A. M., Pence, K., McCall, D., Truong, D. D., Cuglievan, B., Menegaz, B. A., Utama, B., Daw, N. C., Molina, E. R., Zielinski, R. J., Livingston, J. A., Gorlick, R., Mikos, A. G., Kim, M. P., & Ludwig, J. A. (2021). Transcriptional activators YAP/TAZ and AXL orchestrate dedifferentiation, cell fate, and metastasis in human osteosarcoma. Cancer Gene Therapy, 1–14. https://doi.org/10.1038/s41417-020-00281-6 Cite
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LOX-1 and Cancer: An Indissoluble Liaison

The authors outline the role of LOX-1 in tumor spreading and metastasis, evidencing its function in VEGF induction, HIF-1alpha activation, and MMP-9/MMP-2 expression, pushing up the neoangiogenic and the epithelial-mesenchymal transition process in glioblastoma, osteosarcoma, prostate, colon, breast, lung, and pancreatic tumors.
[Cancer Gene Therapy]
Murdocca, M., De Masi, C., Pucci, S., Mango, R., Novelli, G., Di Natale, C., & Sangiuolo, F. (2021). LOX-1 and cancer: an indissoluble liaison. Cancer Gene Therapy, 1–11. https://doi.org/10.1038/s41417-020-00279-0 Cite
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4-Methoxydalbergione Is a Potent Inhibitor of Human Astroglioma U87 Cells In Vitro and In Vivo

The authors evaluated 4‐Methoxydalbergione (4MOD) anti-astroglioma effects on both in vitro and in vivo models. In cultured astroglioma U87 cells, 4MOD inhibited cell proliferation and induced cell apoptosis in a time- and concentration-dependent manner.
[Acta Pharmacologica Sinica]
Li, R., Xu, C., Shen, J., Ren, Q., Chen, D., Lin, M., Huang, R., Li, C., Zhong, R., Luo, Z., Ji, X., & Wu, J. (2020). 4-Methoxydalbergione is a potent inhibitor of human astroglioma U87 cells in vitro and in vivo. Acta Pharmacologica Sinica, 1–9. https://doi.org/10.1038/s41401-020-00560-w Cite
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