osteosarcoma

[Cellular & Molecular Biology Letters] The authors focus on the characteristics and mechanisms by which thymoquinone exerts its cytotoxic effects on bone malignancies.

[Oncogene] Functional screening showed that the m6A demethylase FTO could be a candidate therapeutic target for osteosarcoma (OS). FTO promoted the growth and metastasis of OS in vitro and in vivo.

[Small] Investigators developed a multifunctional nanocomposite bioink based on amine-functionalized copper-doped mesoporous bioactive glass nanoparticles and a hydrogel formulation that improved shape fidelity, and structural stability for extrusion-based bioprinting.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists developed a clinically translatable approach for labeling CAR T cells with iron oxide nanoparticles, which enabled the noninvasive detection of the iron-labeled T cells with magnetic resonance imaging, photoacoustic imaging, and magnetic particle imaging.

[Cancer Research] RNA sequencing of 79 osteosarcoma diagnostic biopsies identified stable independent components that recapitulated the tumor and microenvironment cell composition.

[Scientific Reports] By integrative analysis of RNA-seq, whole-genome sequencing, and methylation data, researchers showed aberrant transposable element (TE) activities associated with dysregulations of TEs in osteosarcoma tumors.