Researchers showed that relatively large anionic nanoparticles administered intraperitoneally selectively accumulated in tumor-associated macrophages.
[Proceedings of the National Academy of Sciences of the United States of America]
6445212 SGBPQ2VA items 1 apa default asc 1
Haber, T., Cornejo, Y. R., Aramburo, S., Flores, L., Cao, P., Liu, A., Mooney, R., Gilchrist, M., Tirughana, R., Nwokafor, U., Abidi, W., Han, E., Dellinger, T., Wakabayashi, M. T., Aboody, K. S., & Berlin, J. M. (2020). Specific targeting of ovarian tumor-associated macrophages by large, anionic nanoparticles. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1917424117 Cite
Scientists developed expandable ovarian cancer organoids in less than three weeks; these organoids captured the characteristics of histological cancer subtypes and replicated the mutational landscape of the primary tumors.
6630899 43A2QTX5 items 1 apa default asc 1
Nanki, Y., Chiyoda, T., Hirasawa, A., Ookubo, A., Itoh, M., Ueno, M., Akahane, T., Kameyama, K., Yamagami, W., Kataoka, F., & Aoki, D. (2020). Patient-derived ovarian cancer organoids capture the genomic profiles of primary tumours applicable for drug sensitivity and resistance testing. Scientific Reports, 10(1), 12581. https://doi.org/10.1038/s41598-020-69488-9 Cite
Scientists showed that circulating ITLN1 has prognostic significance in patients with advanced ovarian cancer. Further studies demonstrated that ITLN1 suppressed lactotransferrin’s effect on ovarian cancer cell invasion potential and proliferation by decreasing MMP1 expression and inducing a metabolic shift in metastatic ovarian cancer cells.
JS InnoPharm Ltd announced the enrollment of the first patient in a Phase I, open-label, monotherapy dose-escalation and expansion study of JSI-1187, the company’s lead investigational drug candidate targeting the enzymes ERK1 and ERK2.
[JS INNOPHARM LTD]
The authors report that chemosensitivity assays using liquid biopsy-derived metastatic epithelial ovarian cancer circulating tumor cells, from 10 patients, nine with stage IIIC and one with stage IV disease, in progression after systemic chemotherapy, submitted for hypoxic isolated abdominal perfusion, were both feasible and useful in predicting response to therapy.
[International Journal of Molecular Sciences]
1254621 WGTRB54W items 1 apa default asc 1
Ovarian clear cell carcinoma cell lines carrying wild-type p53 with low/high mouse double minute 2 homolog (MDM2) expression were investigated in a T-cell co-culture system evaluating T-cell-mediated tumor killing.
[Cell Death Discovery]
Researchers investigated the role of endothelial cell (EC) apoptosis in retinal hypoxia using a mouse model of ischemic retinopathy, in which vessel closure and EC apoptosis caused capillary regression and retinal ischemia followed by neovascularisation.
[Journal of Clinical investigation]