Silencing PTEN in the Fallopian Tube Promotes Enrichment of Cancer Stem Cell-Like Function through Loss of PAX2

Loss of PTEN in fallopian tube epithelium led to the enrichment of CSC markers such as LGR5, WNT4, ALDH1, CD44.
[Cell Death & Disease]
Russo, A., Colina, J. A., Moy, J., Baligod, S., Czarnecki, A. A., Varughese, P., Lantvit, D. D., Dean, M. J., & Burdette, J. E. (2021). Silencing PTEN in the fallopian tube promotes enrichment of cancer stem cell-like function through loss of PAX2. Cell Death & Disease, 12(4), 1–14. https://doi.org/10.1038/s41419-021-03663-2 Cite
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ISG15 Is Downregulated by KLF12 and Implicated in Maintenance of Cancer Stem Cell-Like Features in Cisplatin-Resistant Ovarian Cancer

Investigators identified that both ectopic wild type and nonISGylatable mutant interferon‐stimulated gene 15 (ISG15) expression inhibited CSC‐like phenotypes of cisplatin‐resistant ovarian cancer cells.
[Journal of Cellular and Molecular Medicine]
Zhang, Q., Wang, J., Qiao, H., Huyan, L., Liu, B., Li, C., Jiang, J., Zhao, F., Wang, H., & Yan, J. (n.d.). ISG15 is downregulated by KLF12 and implicated in maintenance of cancer stem cell-like features in cisplatin-resistant ovarian cancer. Journal of Cellular and Molecular Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1111/jcmm.16503 Cite
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Patient-Derived Organoids and High Grade Serous Ovarian Cancer: From Disease Modeling to Personalized Medicine

Scientists discuss recent studies that have characterized the translational potential of patient’s derived organoids to inform on drug sensitivity of high grade serous ovarian cancer patients.
[Journal of Experimental & Clinical Cancer Research]
Nero, C., Vizzielli, G., Lorusso, D., Cesari, E., Daniele, G., Loverro, M., Scambia, G., & Sette, C. (2021). Patient-derived organoids and high grade serous ovarian cancer: from disease modeling to personalized medicine. Journal of Experimental & Clinical Cancer Research, 40(1), 116. https://doi.org/10.1186/s13046-021-01917-7 Cite
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Generation of Two Induced Pluripotent Stem Cell Lines from Blood Cells of a Prostate Cancer Patient Carrying Germline Mutation in CHEK2

The authors generated two iPSC lines ZNHi001-A and ZNHi001-B from a prostate cancer patient carrying germline mutation in CHEK2 which might increase the risk of prostate cancer. Pluripotency and multi-lineage differentiation capacity of the two iPSC lines were confirmed by gene expression and teratoma assay.
[Stem Cell Research]
Liu, R., Qian, K., Xiao, Y., & Jiang, W. (2021). Generation of two induced pluripotent stem cell lines from blood cells of a prostate cancer patient carrying germline mutation in CHEK2. Stem Cell Research, 53, 102299. https://doi.org/10.1016/j.scr.2021.102299 Cite
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Development and Validation for Prognostic Nomogram of Epithelial Ovarian Cancer Recurrence Based on Circulating Tumor Cells and Epithelial–Mesenchymal Transition

Scientists used CanPatrol circulating tumor cells (CTC)-enrichment technique to detect CTCs from blood samples and classify subpopulations into epithelial, mesenchymal, and hybrids.
[Scientific Reports]
Yang, J., Ma, J., Jin, Y., Cheng, S., Huang, S., Zhang, N., & Wang, Y. (2021). Development and validation for prognostic nomogram of epithelial ovarian cancer recurrence based on circulating tumor cells and epithelial–mesenchymal transition. Scientific Reports, 11(1), 6540. https://doi.org/10.1038/s41598-021-86122-4 Cite
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Anixa Biosciences and Moffitt Cancer Center File IND Application for Ovarian Cancer CAR-T Therapy

Anixa Biosciences, Inc. announced that an IND (Investigational New Drug) application for its ovarian cancer CAR-T therapy has been filed with the FDA.
[Anixa Biosciences, Inc.]
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Anti-Cancer Effects of Polyphenol-Rich Sugarcane Extract

Investigators showed that polyphenol-rich sugarcane extract exerted anti-cancer properties on a range of cancer cells including human and mouse colon cancer cells lines; human lung cancer, human ovarian cancer, pro-monocytic human leukemia and mouse melanoma cell lines
[PLoS One]
Prakash, M. D., Stojanovska, L., Feehan, J., Nurgali, K., Donald, E. L., Plebanski, M., Flavel, M., Kitchen, B., & Apostolopoulos, V. (2021). Anti-cancer effects of polyphenol-rich sugarcane extract. PLOS ONE, 16(3), e0247492. https://doi.org/10.1371/journal.pone.0247492 Cite
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Personalized Cancer Vaccine Strategy Elicits Polyfunctional T Cells and Demonstrates Clinical Benefits in Ovarian Cancer

Scientists hypothesized that adding acetylsalicylic acid and low-dose interleukin-2 would increase the vaccine efficacy in a recurrent advanced ovarian cancer Phase I trial.
[npj Vaccines]
Tanyi, J. L., Chiang, C. L.-L., Chiffelle, J., Thierry, A.-C., Baumgartener, P., Huber, F., Goepfert, C., Tarussio, D., Tissot, S., Torigian, D. A., Nisenbaum, H. L., Stevenson, B. J., Guiren, H. F., Ahmed, R., Huguenin-Bergenat, A.-L., Zsiros, E., Bassani-Sternberg, M., Mick, R., Powell, D. J., … Kandalaft, L. E. (2021). Personalized cancer vaccine strategy elicits polyfunctional T cells and demonstrates clinical benefits in ovarian cancer. Npj Vaccines, 6(1), 1–14. https://doi.org/10.1038/s41541-021-00297-5 Cite
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Pre-Clinical Small Molecule WEHI-7326 Overcomes Drug Resistance and Elicits Response in Patient-Derived Xenograft Models of Human Treatment-Refractory Tumors

Investigators describe results with a new anti-cancer small molecule, WEHI-7326, which caused cell cycle arrest in G2/M, cell death in vitro, and displayed efficacious anti-tumor activity in vivo.
[Cell Death & Disease]
Grohmann, C., Walker, F., Devlin, M., Luo, M.-X., Chüeh, A. C., Doherty, J., Vaillant, F., Ho, G.-Y., Wakefield, M. J., Weeden, C. E., Kamili, A., Murray, J., Po’uha, S. T., Weinstock, J., Kane, S. R., Faux, M. C., Broekhuizen, E., Zheng, Y., Shield-Artin, K., … Lessene, G. (2021). Preclinical small molecule WEHI-7326 overcomes drug resistance and elicits response in patient-derived xenograft models of human treatment-refractory tumors. Cell Death & Disease, 12(3), 1–18. https://doi.org/10.1038/s41419-020-03269-0 Cite
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Synergistic Effects of Type I PRMT and PARP Inhibitors against Non-Small Cell Lung Cancer Cells

The combination of MS023, a type I protein arginine methyltransferases (PRMT) inhibitor, and the PARP inhibitor BMN-673 demonstrated strong synergistic interaction at low nanomolar concentrations in methylthioadenosine phosphorylase-negative NSCLC cell lines A549, SK-LU-1 and HCC4006.
[Clinical Epigenetics]
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Endothelin-1 Drives Invadopodia and Interaction with Mesothelial Cells through ILK

Researchers report that β-arrestin1 (β-arr1) links the integrin-linked kinase (ILK)/βPIX complex to activate Rac3 GTPase, acting as a central node in the adhesion-based extracellular matrix sensing and degradation.
[Cell Reports]
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