Specific Targeting of Ovarian Tumor-Associated Macrophages by Large, Anionic Nanoparticles

Researchers showed that relatively large anionic nanoparticles administered intraperitoneally selectively accumulated in tumor-associated macrophages.
[Proceedings of the National Academy of Sciences of the United States of America]
Haber, T., Cornejo, Y. R., Aramburo, S., Flores, L., Cao, P., Liu, A., Mooney, R., Gilchrist, M., Tirughana, R., Nwokafor, U., Abidi, W., Han, E., Dellinger, T., Wakabayashi, M. T., Aboody, K. S., & Berlin, J. M. (2020). Specific targeting of ovarian tumor-associated macrophages by large, anionic nanoparticles. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1917424117 Cite
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Patient-Derived Ovarian Cancer Organoids Capture the Genomic Profiles of Primary Tumors Applicable for Drug Sensitivity and Resistance Testing

Scientists developed expandable ovarian cancer organoids in less than three weeks; these organoids captured the characteristics of histological cancer subtypes and replicated the mutational landscape of the primary tumors.
[Scientific Reports]
Nanki, Y., Chiyoda, T., Hirasawa, A., Ookubo, A., Itoh, M., Ueno, M., Akahane, T., Kameyama, K., Yamagami, W., Kataoka, F., & Aoki, D. (2020). Patient-derived ovarian cancer organoids capture the genomic profiles of primary tumours applicable for drug sensitivity and resistance testing. Scientific Reports, 10(1), 12581. https://doi.org/10.1038/s41598-020-69488-9 Cite
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ITLN1 Modulates Invasive Potential and Metabolic Reprogramming of Ovarian Cancer Cells in Omental Microenvironment

Scientists showed that circulating ITLN1 has prognostic significance in patients with advanced ovarian cancer. Further studies demonstrated that ITLN1 suppressed lactotransferrin’s effect on ovarian cancer cell invasion potential and proliferation by decreasing MMP1 expression and inducing a metabolic shift in metastatic ovarian cancer cells.
[Nature Communications]
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JS InnoPharm Announces First Patient Dosed with JSI-1187, a Selective ERK Inhibitor, in Phase I Clinical Study for Advanced Solid Tumors with MAPK Pathway Mutations

JS InnoPharm Ltd announced the enrollment of the first patient in a Phase I, open-label, monotherapy dose-escalation and expansion study of JSI-1187, the company’s lead investigational drug candidate targeting the enzymes ERK1 and ERK2.
[JS INNOPHARM LTD]
Press Release

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A Pilot Study of the Predictive Potential of Chemosensitivity and Gene Expression Assays Using Circulating Tumor Cells from Patients with Recurrent Ovarian Cancer

The authors report that chemosensitivity assays using liquid biopsy-derived metastatic epithelial ovarian cancer circulating tumor cells, from 10 patients, nine with stage IIIC and one with stage IV disease, in progression after systemic chemotherapy, submitted for hypoxic isolated abdominal perfusion, were both feasible and useful in predicting response to therapy.
[International Journal of Molecular Sciences]
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AMG-232 Sensitizes High MDM2-Expressing Tumor Cells to T-Cell-Mediated Killing

Ovarian clear cell carcinoma cell lines carrying wild-type p53 with low/high mouse double minute 2 homolog (MDM2) expression were investigated in a T-cell co-culture system evaluating T-cell-mediated tumor killing.
[Cell Death Discovery]
Sahin, I., Zhang, S., Navaraj, A., Zhou, L., Dizon, D., Safran, H., & El-Deiry, W. S. (2020). AMG-232 sensitizes high MDM2-expressing tumor cells to T-cell-mediated killing. Cell Death Discovery, 6(1), 1–7. https://doi.org/10.1038/s41420-020-0292-1 Cite
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Blocking Endothelial Apoptosis Revascularises the Retina in a Model of Ischemic Retinopathy

Researchers investigated the role of endothelial cell (EC) apoptosis in retinal hypoxia using a mouse model of ischemic retinopathy, in which vessel closure and EC apoptosis caused capillary regression and retinal ischemia followed by neovascularisation.
[Journal of Clinical investigation]
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