COL11A1 Activates Cancer-Associated Fibroblasts by Modulating TGF-β3 through the NF-κB/IGFBP2 Axis in Ovarian Cancer Cells

Collagen type XI alpha 1 (COL11A1) is overexpressed in cancer-associated fibroblasts (CAFs); therefore this study examined its role during CAF activation in epithelial ovarian cancer.
[Oncogene]
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A Human Multi-Cellular Model Shows How Platelets Drive Production of Diseased Extracellular Matrix and Tissue Invasion

Prompted by findings in patient biopsies, scientists used the model to investigate the role of platelets in malignant cell invasion and ECM production.
[iScience]
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Neutralization of PD-L2 is Essential for Overcoming Immune Checkpoint Blockade Resistance in Ovarian Cancer

The authors found that the immune checkpoint ligand PD-L2 is robustly expressed in patient samples of ovarian cancers and other malignancies exhibiting suboptimal response to immune checkpoint blockade (ICB) but not in cancers that are ICB sensitive.
[Clinical Cancer Research]
Miao, Y. R., Thakkar, K. N., Qian, J., Kariolis, M. S., Huang, W., Nandagopal, S., Yang, T. T. C., Diep, A. N., Cherf, G. M., Xu, Y., Moon, E. J., Xiao, Y., Alemany, H., Li, T., Yu, W., Wei, B., Rankin, E. B., & Giaccia, A. J. (2021). Neutralization of PD-L2 is Essential for Overcoming Immune Checkpoint Blockade Resistance in Ovarian Cancer. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-20-0482 Cite
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Clinical Significance of Circulating Tumor Cell Related Markers in Patients with Epithelial Ovarian Cancer Before and after Adjuvant Chemotherapy

Using quantitative real-time PCR, the authors evaluated the expression of EPCAM, MUC1, CEA, HE4 and CA125 mRNAs, as putative markers of circulating tumor cells, in the blood of 51 epithelial ovarian cancer patients before and/or after adjuvant chemotherapy.
[Scientific Reports]
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Adipocyte-Like Signature in Ovarian Cancer Minimal Residual Disease Identifies Metabolic Vulnerabilities of Tumor Initiating Cells

Investigators performed dense multi-region transcriptomics analysis of paired biopsies from 17 ovarian cancer patients before and after chemotherapy.
[JCI Insight]
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Truncated Actin-Targeting Macrolide Derivative Blocks Cancer Cell Motility and Invasion of Extracellular Matrix

Through structure-activity relationship studies focused on the actin-binding tail region of MycB, scientists identified a potent truncated derivative that inhibits polymerization of G-actin and severs F-actin by binding to actin’s barbed end cleft.
[Journal of the American Chemical Society]
Truncated Actin-Targeting Macrolide Derivative Blocks Cancer Cell Motility and Invasion of Extracellular Matrix | Journal of the American Chemical Society. (n.d.). Retrieved May 6, 2021, from https://pubs.acs.org/doi/10.1021/jacs.0c12404 Cite
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SynNotch CAR Circuits Enhance Solid Tumor Recognition and Promote Persistent Antitumor Activity in Mouse Models

Researchers improved the specificity and persistent antitumor activity of therapeutic T cells with synthetic Notch CAR circuits.
[Science Translational Medicine]
Hyrenius-Wittsten, A., Su, Y., Park, M., Garcia, J. M., Alavi, J., Perry, N., Montgomery, G., Liu, B., & Roybal, K. T. (2021). SynNotch CAR circuits enhance solid tumor recognition and promote persistent antitumor activity in mouse models. Science Translational Medicine, 13(591). https://doi.org/10.1126/scitranslmed.abd8836 Cite
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Triptolide Suppresses the Growth and Metastasis of Non-small Cell Lung Cancer by Inhibiting β-Catenin-Mediated Epithelial–Mesenchymal Transition

Researchers investigated the effect of triptolide on the migration and invasion of non-small cell lung cancer cell lines.
[Acta Pharmacologica Sinica]
Deng, Q., Lei, X., Zhong, Y., Chen, M., Ke, Y., Li, Z., Chen, J., Huang, L., Zhang, Y., Liang, L., Lin, Z., Liu, Q., Li, S., & Yu, X. (2021). Triptolide suppresses the growth and metastasis of non-small cell lung cancer by inhibiting β-catenin-mediated epithelial–mesenchymal transition. Acta Pharmacologica Sinica, 1–12. https://doi.org/10.1038/s41401-021-00657-w Cite
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BBIT20 Inhibits Homologous DNA Repair with Disruption of the BRCA1-BARD1 Interaction in Breast and Ovarian Cancer

To unveil dregamine 5‐bromo‐pyridin‐2‐ylhydrazone (BBIT20), antitumor activity and underlying molecular mechanism of action, 2D and 3D cell cultures, patient-derived cell lines and xenograft mouse models were used.
[British Journal of Pharmacology]
Raimundo, L., Paterna, Â., Calheiros, J., Ribeiro, J., Cardoso, D., Piga, I., Neto, S. J., Hegan, D., Glazer, P. M., Indraccolo, S., Mulhovo, S., Costa, J. L., Ferreira, M.-J. U., & Saraiva, L. (n.d.). BBIT20 inhibits homologous DNA repair with disruption of the BRCA1-BARD1 interaction in breast and ovarian cancer. British Journal of Pharmacology, n/a(n/a). https://doi.org/https://doi.org/10.1111/bph.15506 Cite
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Anti-Proliferative and Apoptotic Effect of Gemini Curcumin in p53-Wild Type and p53-Mutant Colorectal Cancer Cell Lines

The toxicity of Gemini-Cur on HT-29 and HCT116 was studied through MTT, uptake kinetics, fluorescence microscopy, annexin V/FITC, and cell cycle assays.
[International Journal of Pharmaceutics]
Ebrahimi, M., Babaei, E., Neri, F., & Feizi, M. A. H. (2021). Anti-proliferative and apoptotic effect of gemini curcumin in p53-wild type and p53-mutant colorectal cancer cell lines. International Journal of Pharmaceutics, 601, 120592. https://doi.org/10.1016/j.ijpharm.2021.120592 Cite
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The Cancer Stem Cell Niche in Ovarian Cancer and Its Impact on Immune Surveillance

Investigators summarize current evidence-based knowledge on the cancer stem cell niche within the ovarian cancer tumour microenvironment and its effect on immune surveillance.
[International Journal of Molecular Sciences]
Jain, S., Annett, S. L., Morgan, M. P., & Robson, T. (2021). The Cancer Stem Cell Niche in Ovarian Cancer and Its Impact on Immune Surveillance. International Journal of Molecular Sciences, 22(8), 4091. https://doi.org/10.3390/ijms22084091 Cite
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