Characterization of Ascites- and Tumor-Infiltrating γδ T Cells Reveals Distinct Repertoires and a Beneficial Role in Ovarian Cancer

The authors demonstrated that tumor-infiltrating γδ T cells isolated from patients with ovarian cancer have distinct T cell receptors and exhibit more innate-like functions compared to blood- or ascites-derived γδ T cells.
[Science Translational Medicine]
Foord, E., Arruda, L. C. M., Gaballa, A., Klynning, C., & Uhlin, M. (2021). Characterization of ascites- and tumor-infiltrating γδ T cells reveals distinct repertoires and a beneficial role in ovarian cancer. Science Translational Medicine, 13(577). https://doi.org/10.1126/scitranslmed.abb0192 Cite
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Effect of SSRI Exposure on the Proliferation Rate and Glucose Uptake in Breast and Ovary Cancer Cell Lines

The authors examined whether three commonly prescribed selective serotonin reuptake inhibitors (SSRIs), fluoxetine, sertraline and citalopram, affected proliferation or glucose uptake of human breast and ovarian cancer cell lines characterized by different malignancies and metastatic potential.
[Scientific Reports]
Stapel, B., Melzer, C., von der Ohe, J., Hillemanns, P., Bleich, S., Kahl, K. G., & Hass, R. (2021). Effect of SSRI exposure on the proliferation rate and glucose uptake in breast and ovary cancer cell lines. Scientific Reports, 11(1), 1250. https://doi.org/10.1038/s41598-020-80850-9 Cite
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Zentalis Pharmaceuticals Announces the Initiation of Multiple Early-Stage Clinical Trials

Zentalis Pharmaceuticals, Inc. announced that the company has initiated patient dosing in three new combination and monotherapy clinical trials.
[Zentalis Pharmaceuticals, Inc.]
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The Mutational Load and a T-Cell Inflamed Tumor Phenotype Identify Ovarian Cancer Patients Rendering Tumor-Reactive T Cells from PD-1+ Tumor-Infiltrating Lymphocytes

Tumor-reactive tumor-infiltrating lymphocytes were detected in half of patients and were exclusively present in cells derived from the PD-1+ fraction.
[British Journal of Cancer]
Salas-Benito, D., Conde, E., Tamayo-Uria, I., Mancheño, U., Elizalde, E., Garcia-Ros, D., Aramendia, J. M., Muruzabal, J. C., Alcaide, J., Guillen-Grima, F., Minguez, J. A., Amores-Tirado, J., Gonzalez-Martin, A., Sarobe, P., Lasarte, J. J., Ponz-Sarvise, M., De Andrea, C. E., & Hervas-Stubbs, S. (2021). The mutational load and a T-cell inflamed tumour phenotype identify ovarian cancer patients rendering tumour-reactive T cells from PD-1 + tumour-infiltrating lymphocytes. British Journal of Cancer, 1–12. https://doi.org/10.1038/s41416-020-01218-4 Cite
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Intratumoral Immunostimulatory AdCD40L Gene Therapy in Patients with Advanced Solid Tumors

Scientists present the results of repeated intratumoral injections of AdCD40L in seven patients with metastatic solid cancer.
[Cancer Gene Therapy]
Irenaeus, S., Hellström, V., Wenthe, J., Krause, J., Sundin, A., Ahlström, H., Tufveson, G., Tötterman, T. H., Loskog, A., & Ullenhag, G. J. (2020). Intratumoral immunostimulatory AdCD40L gene therapy in patients with advanced solid tumors. Cancer Gene Therapy, 1–10. https://doi.org/10.1038/s41417-020-00271-8 Cite
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A Review of the Effects and Molecular Mechanisms of Dimethylcurcumin (ASC-J9) on Androgen Receptor-Related Diseases

The effects and molecular mechanisms of ASC‐J9 on various AR‐associated diseases are summarized. Importantly, the effects of ASC‐J9 and AR antagonists enzalutamide/bicalutamide on prostate cancer are compared in detail and crucial differences are highlighted.
[Chemical Biology & Drug Design]
Hu, H., Zhou, H., & Xu, D. (n.d.). A review of the effects and molecular mechanisms of dimethylcurcumin (ASC-J9) on androgen receptor-related diseases. Chemical Biology & Drug Design, n/a(n/a). https://doi.org/https://doi.org/10.1111/cbdd.13811 Cite
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Harpoon Therapeutics Reports Clinical Progress Across All Four TriTAC® Pipeline Development Programs

Harpoon Therapeutics, Inc. has provided a pipeline update and reported a confirmed partial response based on RECIST v1.1 criteria for its most advanced program, HPN424 for the treatment of metastatic castration-resistant prostate cancer. In the 160ng/kg cohort, which is the highest fixed dose tested to date, seven patients have been enrolled and one patient has achieved a confirmed partial response.
[Harpoon Therapeutics, Inc.]
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Epigenomic Reprogramming toward Mesenchymal-Epithelial Transition in Ovarian-Cancer-Associated Mesenchymal Stem Cells Drives Metastasis

The authors show that, in addition to cancer cell epithelial-to-mesenchymal transition, ovarian cancer cell metastasis relies on an epigenomic mesenchymal-to-epithelial transition in host MSCs. These reprogrammed MSCs, termed carcinoma-associated MSCs, acquire pro-tumorigenic functions and directly bind cancer cells to serve as a metastatic driver/chaperone.
[Cell Reports]
Fan, H., Atiya, H. I., Wang, Y., Pisanic, T. R., Wang, T.-H., Shih, I.-M., Foy, K. K., Frisbie, L., Buckanovich, R. J., Chomiak, A. A., Tiedemann, R. L., Rothbart, S. B., Chandler, C., Shen, H., & Coffman, L. G. (2020). Epigenomic Reprogramming toward Mesenchymal-Epithelial Transition in Ovarian-Cancer-Associated Mesenchymal Stem Cells Drives Metastasis. Cell Reports, 33(10). https://doi.org/10.1016/j.celrep.2020.108473 Cite
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Tumor Derived UBR5 Promotes Ovarian Cancer Growth and Metastasis through Inducing Immunosuppressive Macrophages

The authors demonstrated that tumor-derived UBR5, an E3 ligase overexpressed in human ovarian cancer (OC) associated with poor prognosis, was essential for OC progression principally by promoting tumor-associated macrophage recruitment and activation via key chemokines and cytokines.
[Nature Communications]
Song, M., Yeku, O. O., Rafiq, S., Purdon, T., Dong, X., Zhu, L., Zhang, T., Wang, H., Yu, Z., Mai, J., Shen, H., Nixon, B., Li, M., Brentjens, R. J., & Ma, X. (2020). Tumor derived UBR5 promotes ovarian cancer growth and metastasis through inducing immunosuppressive macrophages. Nature Communications, 11(1), 6298. https://doi.org/10.1038/s41467-020-20140-0 Cite
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Insight into Cisplatin-Resistance Signaling of W1 Ovarian Cancer Cells Emerges mTOR and HSP27 as Targets for Sensitization Strategies

The microenvironment possesses a strong impact on the tumor chemoresistance when cells bind to components of the ECM. Scientists elucidated the signaling pathways of cisplatin resistance in W1 ovarian cancer cells binding to collagen type 1 and signaling interference with constitutive cisplatin resistance in W1CR cells to discover the targets for sensitization.
[International Journal of Molecular Sciences]
Wantoch von Rekowski, K., König, P., Henze, S., Schlesinger, M., Zawierucha, P., Januchowski, R., & Bendas, G. (2020). Insight into Cisplatin-Resistance Signaling of W1 Ovarian Cancer Cells Emerges mTOR and HSP27 as Targets for Sensitization Strategies. International Journal of Molecular Sciences, 21(23), 9240. https://doi.org/10.3390/ijms21239240 Cite
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Therapeutic Potential of PARP Inhibitors in the Treatment of Metastatic Castration-Resistant Prostate Cancer

The authors expand on the clinical development of PARP inhibitors (PARPis) in metastatic castration-resistant prostate cancer, discuss potential biomarkers that may predict successful tumor control, and summarize present and future clinical research on PARPis in the metastatic disease landscape.
[Cancers]
Jang, A., Sartor, O., Barata, P. C., & Paller, C. J. (2020). Therapeutic Potential of PARP Inhibitors in the Treatment of Metastatic Castration-Resistant Prostate Cancer. Cancers, 12(11), 3467. https://doi.org/10.3390/cancers12113467 Cite
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