ovarian cancer

[npj Precision Oncology] Investigators described elevated infiltration by regulatory T cells as the most common feature, while other lymphocyte subsets and also expression of immune-regulatory molecules on tumor-infiltrating lymphocytes showed site-specific variation.

[Molecular Metabolism] The authors elucidated the role of ovarian cancer microenvironment in regulating the immunosuppressive function of CD11b+Gr1+ myeloid cells.

[Oncogene] Collagen type XI alpha 1 (COL11A1) is overexpressed in cancer-associated fibroblasts (CAFs); therefore this study examined its role during CAF activation in epithelial ovarian cancer.

[iScience] Prompted by findings in patient biopsies, scientists used the model to investigate the role of platelets in malignant cell invasion and ECM production.

[Clinical Cancer Research] The authors found that the immune checkpoint ligand PD-L2 is robustly expressed in patient samples of ovarian cancers and other malignancies exhibiting suboptimal response to immune checkpoint blockade (ICB) but not in cancers that are ICB sensitive.

[Scientific Reports] Using quantitative real-time PCR, the authors evaluated the expression of EPCAM, MUC1, CEA, HE4 and CA125 mRNAs, as putative markers of circulating tumor cells, in the blood of 51 epithelial ovarian cancer patients before and/or after adjuvant chemotherapy.