p16

[Cell Reports] The authors identified critical polycomb repressive complex 2 (PRC2) functional sites at high resolution. They fused a computationally designed protein, EED binder, which competed with EZH2 and thereby inhibited PRC2 function, to dCas9 to allow for PRC2 inhibition at a precise locus using gRNA.

[Journal of Agricultural and Food Chemistry] Cucurbitacin E (CE) belongs to the triterpenoids and has received substantial attention for its antineoplastic property. The authors revealed that CE significantly induced cellular senescence in colorectal cancer cells.

[Cancer Gene Therapy] Investigators overexpressed MYC in freshly isolated human primary melanocytes and studied the effects on melanocytic proliferation and differentiation.

[International Journal of Cardiology] Researchers revealed that programmed cell death 5 (Pdcd5) deficiency attenuated cardiac aging by reducing cellular senescence and apoptosis, and increasing Parkin-mediated mitophagy, likely through p53.

[Expert Review of Molecular Diagnostics] Scientists cover the recent advancements in the identification of proteomic/genomic/epigenomic/transcriptomic biomarkers for predicting hepatocellular carcinoma treatment efficacy with the use of multi-kinase inhibitors, CDK4/6 inhibitors, and immune checkpoint inhibitors.

[Mediators of Inflammation] Peripheral blood endothelial progenitor cells were isolated from nonsmoking non-chronic obstructive pulmonary disease (COPD), smoking non-COPD, and smoking COPD patients. The expressions of p16, p300, and senescence-related genes were detected by RT-PCR and Western Blot.