Hypoxia-Inducible Factor-2α Mediates Senescence-Associated Intrinsic Mechanisms of Age-Related Bone Loss

Inhibition of senescence-induced upregulation of hypoxia-inducible factor-2α expression during matrix maturation, but not during the proliferation stage of osteoblast differentiation, reversed the age-related decrease in Runx2 and Ocn expression.
[Experimental and Molecular Medicine]
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H2A.Z Overexpression Suppresses Senescence and Chemosensitivity in Pancreatic Ductal Adenocarcinoma

Scientists demonstrated that the histone variant H2A.Z was highly expressed in PDAC cell lines and PDAC patients and that its overexpression correlated with poor prognosis.
[Oncogene]
Ávila-López, P. A., Guerrero, G., Nuñez-Martínez, H. N., Peralta-Alvarez, C. A., Hernández-Montes, G., Álvarez-Hilario, L. G., Herrera-Goepfert, R., Albores-Saavedra, J., Villegas-Sepúlveda, N., Cedillo-Barrón, L., Montes-Gómez, A. E., Vargas, M., Schnoor, M., Recillas-Targa, F., & Hernández-Rivas, R. (2021). H2A.Z overexpression suppresses senescence and chemosensitivity in pancreatic ductal adenocarcinoma. Oncogene, 1–16. https://doi.org/10.1038/s41388-021-01664-1 Cite
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The Inhibitory Effect of Human DEFA5 in Growth of Gastric Cancer by Targeting BMI‐1

DEFA5 directly bound with BMI‐1, which subsequently decreased its binding at the CDKN2a locus and upregulated the expression of two cyclin‐dependent kinase inhibitors, p16 and p19.
[Cancer Science]
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MiR-22, Regulated by MeCP2, Suppresses Gastric Cancer Cell Proliferation by Inducing a Deficiency in Endogenous S-Adenosylmethionine

Scientists revealed that the metabolic profiles in gastric cancer tissues were altered. S-adenosylmethionine, a universal methyl donor for histone and DNA methylation, which is specifically involved in the epigenetic maintenance of cancer cells, was found increased.
[Oncogenesis]
Tong, D., Zhang, J., Wang, X., Li, Q., Liu, L., Lu, A., Guo, B., Yang, J., Ni, L., Qin, H., Zhao, L., & Huang, C. (2020). MiR-22 , regulated by MeCP2, suppresses gastric cancer cell proliferation by inducing a deficiency in endogenous S-adenosylmethionine. Oncogenesis, 9(11), 1–16. https://doi.org/10.1038/s41389-020-00281-z Cite
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Expression and Role of p16 and GLUT1 in Malignant Diseases and Lung Cancer: A Review

Non‐small cell lung cancer (NSCLC) is the leading cause of cancer death and in most cases it is often diagnosed at an advanced stage. Many genetic and microenvironmental factors are able to modify the cell cycle inducing carcinogenesis and tumor growth.
[Thoracic Cancer]
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Oxidative Stress-Mediated Mitochondrial Dysfunction Facilitates Mesenchymal Stem Cell Senescence in Ankylosing Spondylitis

Researchers found that ankylosing spondylitis (AS) serum facilitated senescence of MSCs in vitro, and articular tissues from AS patients exhibited higher expression levels of the cell cycle arrest-related proteins p53, p21 and p16.
[Cell Death & Disease]
Ye, G., Xie, Z., Zeng, H., Wang, P., Li, J., Zheng, G., Wang, S., Cao, Q., Li, M., Liu, W., Cen, S., Li, Z., Wu, Y., Ye, Z., & Shen, H. (2020). Oxidative stress-mediated mitochondrial dysfunction facilitates mesenchymal stem cell senescence in ankylosing spondylitis. Cell Death & Disease, 11(9), 1–13. https://doi.org/10.1038/s41419-020-02993-x Cite
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Umbilical Cord Mesenchymal Stem Cells Protect Thymus Structure and Function in Aged C57 Mice by Downregulating Aging-Related Genes and Upregulating Autophagy- and Anti-Oxidative Stress-Related Genes

Scientists studied the effect of allogeneic umbilical cord mesenchymal stem cell transplantation on the structure and function of the thymus in aged C57 mice and provided a new method for the treatment of senile thymic atrophy.
[Aging]
Aging | Umbilical cord mesenchymal stem cells protect thymus structure and function in aged C57 mice by downregulating aging-related genes and upregulating autophagy- and anti-oxidative stress-related genes - Full Text. (n.d.). Retrieved September 16, 2020, from https://www.aging-us.com/article/103594/text Cite
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Effects of Bone Marrow Mesenchymal Stem Cells on Ovarian and Testicular Function in Aging Sprague-Dawley Rats Induced by D-Galactose

[Cell Cycle]
Wang, Z., Yang, T., Liu, S., & Chen, Y. (2020). Effects of bone marrow mesenchymal stem cells on ovarian and testicular function in aging Sprague-Dawley rats induced by D-galactose. Cell Cycle, 0(0), 1–11. https://doi.org/10.1080/15384101.2020.1806434 Cite
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Behavioral Changes in Stem-Cell Potency by HepG2-Exhausted Medium

Investigators studied the expression of stemness-related genes, epigenetic regulators, miRNAs related to stemness, exosomes, the cell-cycle regulators p21 and p53, and the senescence-associated genes.
[Cells]
Balzano, F., Garroni, G., Cruciani, S., Bellu, E., Dei Giudici, S., Oggiano, A., Capobianco, G., Dessole, S., Ventura, C., & Maioli, M. (2020). Behavioral Changes in Stem-Cell Potency by HepG2-Exhausted Medium. Cells, 9(8), 1890. https://doi.org/10.3390/cells9081890 Cite
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Mast Cells (MCs) Induce Ductular Reaction Mimicking Liver Injury in Mice via MC-Derived TGF-β1 Signaling

Wild‐type, KitW‐sh, and Mdr2‐/‐ mice lacking l‐histidine decarboxylase were injected with vehicle or PKH26‐tagged murine mast cells pretreated with 0.01% DMSO or the TGF‐βR inhibitor,
[Hepatology]
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Chronic Expression of p16INK4a in the Epidermis Induces Wnt-Mediated Hyperplasia and Promotes Tumor Initiation

Scientists found that prolonged expression of transgenic p16INK4a in the mouse epidermis induced hyperplasia and dysplasia, involving high proliferation rates of keratinocytes not expressing the transgene.
[Nature Communications]
Azazmeh, N., Assouline, B., Winter, E., Ruppo, S., Nevo, Y., Maly, A., Meir, K., Witkiewicz, A. K., Cohen, J., Rizou, S. V., Pikarsky, E., Luxenburg, C., Gorgoulis, V. G., & Ben-Porath, I. (2020). Chronic expression of p16 INK4a in the epidermis induces Wnt-mediated hyperplasia and promotes tumor initiation. Nature Communications, 11(1), 2711. https://doi.org/10.1038/s41467-020-16475-3 Cite
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