Tag results:
p19
Hepatic Cell News
Cellular Heterogeneity and Transcriptomic Profiles during Intrahepatic Cholangiocarcinoma Initiation and Progression
[Hepatology] Researchers performed single-cell RNA-sequencing using AKT/NICD-induced mouse intrahepatic cholangiocarcinoma tissues at early, middle, and late stages.
Endothelial Cell News
Th17/IL-17 Induces Endothelial Cell Senescence via Activation of NF-κB/p53/RB Signaling Pathway
[Laboratory Investigation] The proportion of Th17 cells in the spleen and the expression levels of IL-17A, IL-6, and vascular cell adhesion molecule- in mice of different ages were increased with aging.
Cancer Stem Cell News
RANK Links Senescence to Stemness in the Mammary Epithelia, Delaying Tumor Onset but Increasing Tumor Aggressiveness
[Developmental Cell] The authors uncovered a dual role for Rank in the mammary epithelia: Rank induced senescence and stemness, delaying tumor initiation but increasing tumor aggressiveness.
Intestinal Cell News
The Inhibitory Effect of Human DEFA5 in Growth of Gastric Cancer by Targeting BMI‐1
[Cancer Science] DEFA5 directly bound with BMI‐1, which subsequently decreased its binding at the CDKN2a locus and upregulated the expression of two cyclin‐dependent kinase inhibitors, p16 and p19.
Mesenchymal Cell News
Behavioral Changes in Stem-Cell Potency by HepG2-Exhausted Medium
[Cells] Investigators studied the expression of stemness-related genes, epigenetic regulators, miRNAs related to stemness, exosomes, the cell-cycle regulators p21 and p53, and the senescence-associated genes.