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p19

Cellular Heterogeneity and Transcriptomic Profiles during Intrahepatic Cholangiocarcinoma Initiation and Progression

[Hepatology] Researchers performed single-cell RNA-sequencing using AKT/NICD-induced mouse intrahepatic cholangiocarcinoma tissues at early, middle, and late stages.

Th17/IL-17 Induces Endothelial Cell Senescence via Activation of NF-κB/p53/RB Signaling Pathway

[Laboratory Investigation] The proportion of Th17 cells in the spleen and the expression levels of IL-17A, IL-6, and vascular cell adhesion molecule- in mice of different ages were increased with aging.

RANK Links Senescence to Stemness in the Mammary Epithelia, Delaying Tumor Onset but Increasing Tumor Aggressiveness

[Developmental Cell] The authors uncovered a dual role for Rank in the mammary epithelia: Rank induced senescence and stemness, delaying tumor initiation but increasing tumor aggressiveness.

The Inhibitory Effect of Human DEFA5 in Growth of Gastric Cancer by Targeting BMI‐1

[Cancer Science] DEFA5 directly bound with BMI‐1, which subsequently decreased its binding at the CDKN2a locus and upregulated the expression of two cyclin‐dependent kinase inhibitors, p16 and p19.

Behavioral Changes in Stem-Cell Potency by HepG2-Exhausted Medium

[Cells] Investigators studied the expression of stemness-related genes, epigenetic regulators, miRNAs related to stemness, exosomes, the cell-cycle regulators p21 and p53, and the senescence-associated genes.

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