Exosome-Transmitted miRNA-335-5p Promotes Colorectal Cancer Invasion and Metastasis by Facilitating Epithelial-Mesenchymal Transition via Targeting RASA1

The authors found that exosomes derived from metastatic colorectal cancer (CRC) cell line SW620 promoted migration, invasion, and epithelial-mesenchymal transition of CRC cells.
[Molecular Therapy-Nucleic Acids]
Sun, X., Lin, F., Sun, W., Zhu, W., Fang, D., Luo, L., Li, S., Zhang, W., & Jiang, L. (2021). Exosome-transmitted miRNA-335-5p promotes colorectal cancer invasion and metastasis by facilitating epithelial-mesenchymal transition via targeting RASA1. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2021.02.022 Cite
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ZNF674-AS1 Antagonizes miR-423-3p to Induce G0/G1 Cell Cycle Arrest in Non-small Cell Lung Cancer Cells

Researchers investigated the expression of ZNF674-AS1 in 83 pairs of NSCLC specimens and adjacent noncancerous lung tissues. The clinical significance of ZNF674-AS1 in NSCLC was analyzed. The role of ZNF674-AS1 in NSCLC growth and cell cycle progression was explored.
[Cellular & Molecular Biology Letters]
Liu, Y., Huang, R., Xie, D., Lin, X., & Zheng, L. (2021). ZNF674-AS1 antagonizes miR-423-3p to induce G0/G1 cell cycle arrest in non-small cell lung cancer cells. Cellular & Molecular Biology Letters, 26(1), 6. https://doi.org/10.1186/s11658-021-00247-y Cite
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C2orf40 Inhibits Hepatocellular Carcinoma through UBR5-Dependent or p53-Independent Mechanisms

The recovery of C2orf40 expression in hepatocellular carcinoma cell lines could induce G0/G1 phase arrest and apoptosis, and also inhibit cell migration and invasion by reversing the epithelial–mesenchymal transition process, both in vivo and in vitro.
[Journal of Gastroenterology and Hepatology]
Wu, Y., Xiang, Q., Lv, X., Xiang, X., Feng, Z., Tian, S., Tang, J., Xiang, T., & Gong, J. (n.d.). C2orf40 inhibits hepatocellular carcinoma through UBR5-dependent or p53-independent mechanisms. Journal of Gastroenterology and Hepatology, n/a(n/a). https://doi.org/https://doi.org/10.1111/jgh.15441 Cite
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NAMPT/SIRT2-Mediated Inhibition of the p53-p21 Signaling Pathway Is Indispensable for Maintenance and Hematopoietic Differentiation of Human iPS Cells

Investigators demonstrated that nicotinamide phosphoribosyltransferase (NAMPT) is indispensable for the maintenance, survival, and hematopoietic differentiation of induced pluripotent stem cells.
[Stem Cell Research & Therapy]
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Human Umbilical Vein Endothelial Cells-Derived MicroRNA-203-Containing Extracellular Vesicles Alleviate Non-Small-Cell Lung Cancer Progression through Modulating the DTL/p21 Axis

The authors investigated the potential of extracellular vesicles derived from human umbilical vein endothelial cells to transfer miR-203 to affect the progression of non-small cell lung cancer (NSCLC). miR-203 and p21 were poorly expressed while DTL was highly expressed both in NSCLC tissues and cell lines.
[Cancer Gene Therapy]
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Human Umbilical Vein Endothelial Cells-Derived microRNA-203-Containing Extracellular Vesicles Alleviate Non-Small-Cell Lung Cancer Progression through Modulating the DTL/p21 Axis

The authors investigated the potential of extracellular vesicles derived from HUVECs to transfer miR-203 to affect the progression of non-small cell lung cancer.
[Cancer Gene Therapy]
Ma, T., Hu, Y., Guo, Y., & Zhang, Q. (2021). Human umbilical vein endothelial cells-derived microRNA-203-containing extracellular vesicles alleviate non-small-cell lung cancer progression through modulating the DTL/p21 axis. Cancer Gene Therapy, 1–14. https://doi.org/10.1038/s41417-020-00292-3 Cite
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SHCBP1 Interacting with EOGT Enhances O-GlcNAcylation of NOTCH1 and Promotes the Development of Pancreatic Cancer

Scientists hypothesized that SHCBP1 and EOGT could mediate PDAC progression by influencing NOTCH1 O-GlcNAcylation.
[Genomics]
Yang, C., Hu, J.-F., Zhan, Q., Wang, Z.-W., Li, G., Pan, J.-J., Huang, L., Liao, C.-Y., Huang, Y., Tian, Y.-F., Shen, B.-Y., Chen, J.-Z., Wang, Y.-D., & Chen, S. (2021). SHCBP1 interacting with EOGT enhances O-GlcNAcylation of NOTCH1 and promotes the development of pancreatic cancer. Genomics. https://doi.org/10.1016/j.ygeno.2021.01.010 Cite
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Potential Chemotherapeutic Effect of Betalain against Human Non‐Small Cell Lung Cancer through PI3K/Akt/mTOR Signaling Pathway

Investigators demonstrated that betalain was able to reduce the viability of A549 cells dose dependently with undetectable toxicity toward normal human cells.
[Environmental Toxicology]
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Albanol B from Mulberries Exerts Anti-Cancer Effect through Mitochondria ROS Production in Lung Cancer Cells and Suppresses In Vivo Tumor Growth

Scientists showed that albanol B inhibited the proliferation of four human lung cancer cell lines and induced apoptosis, based on the cleavage of caspase-7 and PARP, as well as the downregulation of Bcl-2.
[International Journal of Molecular Sciences]
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Adult Mesenchymal Stem Cell Aging Interplays with Depressed Mitochondrial Ndufs6

Scientists showed that compared with bone marrow-MSCs isolated from young and aged samples, NADH dehydrogenase iron-sulfur protein 6 (Ndufs6) was depressed in aged MSCs.
[Cell Death & Disease]
Zhang, Y., Guo, L., Han, S., Chen, L., Li, C., Zhang, Z., Hong, Y., Zhang, X., Zhou, X., Jiang, D., Liang, X., Qiu, J., Zhang, J., Li, X., Zhong, S., Liao, C., Yan, B., Tse, H.-F., & Lian, Q. (2020). Adult mesenchymal stem cell ageing interplays with depressed mitochondrial Ndufs6. Cell Death & Disease, 11(12), 1–15. https://doi.org/10.1038/s41419-020-03289-w Cite
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Targeting PAK4 to Reprogram the Vascular Microenvironment and Improve CAR-T Immunotherapy for Glioblastoma

PAK4 knockout induced adhesion protein re-expression in endothelial cells, reduced vascular abnormalities, improved T cell infiltration and inhibits glioblastoma growth in mice.
[Nature Cancer]
Ma, W., Wang, Y., Zhang, R., Yang, F., Zhang, D., Huang, M., Zhang, L., Dorsey, J. F., Binder, Z. A., O’Rourke, D. M., Fraietta, J. A., Gong, Y., & Fan, Y. (2020). Targeting PAK4 to reprogram the vascular microenvironment and improve CAR-T immunotherapy for glioblastoma. Nature Cancer, 1–15. https://doi.org/10.1038/s43018-020-00147-8 Cite
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