Downregulation of TMEM220 Promotes Tumor Progression in Hepatocellular Carcinoma

Through overexpressing TMEM220 in hepatocellular carcinoma cell lines, scientists found that the proliferation of cancer cells was significantly slowed down and metastasis was significantly reduced.
[Cancer Gene Therapy]
Abstract
Bookmark

No account yet? Register

Share

Knockdown of the Prognostic Cancer Stem Cell Marker Musashi-1 Decreases Radio-Resistance While Enhancing Apoptosis in Hormone Receptor-Positive Breast Cancer Cells via p21WAF1/CIP1

Musashi-1 was artificially downregulated in MCF-7 breast cancer cells and implications for cancer stem cell markers, cell apoptosis and apoptosis regulator p21, proliferation and radiation response were analyzed via flow cytometry and colony formation.
[Journal of Cancer Research and Clinical Oncology]
Full Article
Bookmark

No account yet? Register

Share

Effect of the Phenylpyrrole Fungicide Fludioxonil on Cell Proliferation and Cardiac Differentiation in Mouse Embryonic Stem Cells

The potential effect of fludioxonil on cardiac differentiation was evaluated in mouse ESCs. Exposure to fludioxonil resulted in reduced size of mouse embryoid bodies and induced increasing expression levels of the pluripotency markers Oct4, Sox2 and Nanog.
[Reproductive Toxicology]
Abstract
Bookmark

No account yet? Register

Share

ZFP36 Protects Lungs from Intestinal I/R-Induced Injury and Fibrosis through the CREBBP/p53/p21/Bax Pathway

Researchers investigated the involvement of zinc finger protein 36 (ZFP36) and cAMP‐response element-binding protein binding protein (CREBBP) on ischemia–reperfusion (I/R)-induced lung injury in vivo and in vitro.
[Cell Death & Disease]
Full Article
Bookmark

No account yet? Register

Share

Reversal of Senescence-Associated Beta-Galactosidase Expression during In Vitro Three-Dimensional Tissue-Engineering of Human Chondrocytes in a Polymer Scaffold

Researchers evaluated a three-dimensional thermo-reversible gelation polymer matrix environment for its capabilities to reverse cellular senescence.
[Scientific Reports]
Full Article
Bookmark

No account yet? Register

Share

Th17/IL-17 Induces Endothelial Cell Senescence via Activation of NF-κB/p53/RB Signaling Pathway

The proportion of Th17 cells in the spleen and the expression levels of IL-17A, IL-6, and vascular cell adhesion molecule- in mice of different ages were increased with aging.
[Laboratory Investigation]
Zhang, L., Liu, M., Liu, W., Hu, C., Li, H., Deng, J., Cao, Q., Wang, Y., Hu, W., & Li, Q. (2021). Th17/IL-17 induces endothelial cell senescence via activation of NF-κB/p53/Rb signaling pathway. Laboratory Investigation, 1–9. https://doi.org/10.1038/s41374-021-00629-y Cite
Abstract
Bookmark

No account yet? Register

Share

Inverse and Reciprocal Regulation of p53/p21 and BMI-1 Modulates Vasculogenic Differentiation of Dental Pulp Stem Cells

Dental pulp stem cells seeded in biodegradable scaffolds and transplanted into immunodeficient mice generated mature human blood vessels invested with smooth muscle actin-positive mural cells.
[Cell Death & Disease]
Full Article
Bookmark

No account yet? Register

Share

KLHL38 Involvement in Non-Small Cell Lung Cancer Progression via Activation of the Akt Signaling Pathway

Scientists clarified the role of KLHL38 in non-small cell lung cancer (NSCLC). KLHL38 expression was evaluated in tumor and adjacent normal tissues from 241 patients with NSCLC using immunohistochemistry and real-time PCR, and its association with clinicopathological parameters was analyzed.
[Cell Death & Disease]
Xu, Y., Wang, C., Jiang, X., Zhang, Y., Su, H., Jiang, J., Ren, H., & Qiu, X. (2021). KLHL38 involvement in non-small cell lung cancer progression via activation of the Akt signaling pathway. Cell Death & Disease, 12(6), 1–14. https://doi.org/10.1038/s41419-021-03835-0 Cite
Full Article
Bookmark

No account yet? Register

Share

In Vivo Partial Reprogramming of Myofibers Promotes Muscle Regeneration by Remodeling the Stem Cell Niche

Scientists demonstrated that local expression of the Yamanaka reprogramming factors, specifically in myofibers, induced the activation of muscle stem cells or satellite cells, which accelerated muscle regeneration in young mice.
[Nature Communications]
Full Article
Bookmark

No account yet? Register

Share

Kinship of Conditionally Immortalized Cells Derived from Fetal Bone to Human Bone-Derived Mesenchymal Stroma Cells

Investigators studied whether and to what extent the conditionally immortalized cell line hFOB 1.19 could serve as a surrogate model for bone-marrow derived MSCs.
[Scientific Reports]
Full Article
Bookmark

No account yet? Register

Share

Aspartame Induces Cancer Stem Cell Enrichment through p21, NICD and GLI1 in Human PANC-1 Pancreas Adenocarcinoma Cells

Researchers indicated that a high level of glucose exposure does not effect the invasion and migration of PANC-1 cells, while aspartame increases both of these aggressiveness criterias.
[Food and Chemical Toxicology]
Aspartame induces cancer stem cell enrichment through p21, NICD and GLI1 in human PANC-1 pancreas adenocarcinoma cells. (2021). Food and Chemical Toxicology, 112264. https://doi.org/10.1016/j.fct.2021.112264 Cite
Abstract
Bookmark

No account yet? Register

Share
Share