Researchers performed Affymetrix Gene Chip miRNA 4.0 microarray and observed differential regulation of miRNAs (75 upregulated and 199 downregulated) in metastatic MDA-MB-231 cells as compared to immortalized human non-tumorigenic breast epithelial cells.
To investigate which oncogenic drivers co-operate with Zmat3 loss to promote neoplastic transformation, researchers utilized Zmat3 knockout mice in models of c-MYC-driven lymphomagenesis and KrasG12D-driven lung adenocarcinoma development.
[Cell Death & Disease]
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The authors suggest that ROS-mediated genotoxic stress is involved in NaAsO2-induced cell cycle arrest, stemness enhancement and chemoresistance of prostate cancer cells in a p53-independent manner.
[Ecotoxicology and Environmental Safety]
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Zhang, Z.-H., Hong, Q., Zhang, Z.-C., Xing, W.-Y., Xu, S., Tian, Q.-X., Ye, Q.-L., Wang, H., Yu, D.-X., Xie, D.-D., & Xu, D.-X. (2021). ROS-mediated genotoxic stress is involved in NaAsO2-induced cell cycle arrest, stemness enhancement and chemoresistance of prostate cancer cells in a p53-independent manner. Ecotoxicology and Environmental Safety, 208, 111436. https://doi.org/10.1016/j.ecoenv.2020.111436 Cite
Scientists investigated the anticancer effects of botanical component p-hydroxycinnamic acid on the PC-3 cells in vitro model of bone metastatic human prostate cancer.
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Researchers found that miR-512-3p acted as a cell-type-specific tumor suppressor, through targeting HER2, HER3, PIK3R2, and AKT1 transcripts.
[Breast Cancer Research and Treatment]
Three fresh tumor tissues from glioma patients and three normal brain tissues from craniocerebral trauma patients were prepared for high-throughput RNA sequencing.
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Researchers investigated the role of lipoprotein receptor-related protein 6 (LRP6) in heart repair through regulation of cardiomyocyte proliferation. Lrp6 deficiency increased cardiomyocyte cell cycle activity in neonatal, juvenile and adult mice.
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Researchers found that ankylosing spondylitis (AS) serum facilitated senescence of MSCs in vitro, and articular tissues from AS patients exhibited higher expression levels of the cell cycle arrest-related proteins p53, p21 and p16.
[Cell Death & Disease]
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Ye, G., Xie, Z., Zeng, H., Wang, P., Li, J., Zheng, G., Wang, S., Cao, Q., Li, M., Liu, W., Cen, S., Li, Z., Wu, Y., Ye, Z., & Shen, H. (2020). Oxidative stress-mediated mitochondrial dysfunction facilitates mesenchymal stem cell senescence in ankylosing spondylitis. Cell Death & Disease, 11(9), 1–13. https://doi.org/10.1038/s41419-020-02993-x Cite
The authors observed that Poly(ADP-ribose) Polymerase 1 (PARP1) depletion boosted the up-regulation of MyoD targets, such as p57, myogenin, Mef2C and p21, while its re-expression reverted this effect. They also found that PARP1 interacted with some MyoD-binding regions and that its presence, independently of the enzymatic activity, interfered with MyoD recruitment and gene induction.
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A mechanistic investigation showed that EIF1AX inhibited the expression of p21, which is an essential cell cycle regulator.
Scientists found microRNA-107 enhanced radiosensitivity by regulating granulin in prostate cancer cells. MiR-107 was downregulated and granulin was upregulated in response to ionizing radiation in prostate cancer cells.
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MicroRNA-107 enhances radiosensitivity by suppressing granulin in PC-3 prostate cancer cells | Scientific Reports. (n.d.). Retrieved September 3, 2020, from https://www.nature.com/articles/s41598-020-71128-1 Cite