MicroRNA-941 Regulates the Proliferation of Breast Cancer Cells by Altering Histone H3 Ser 10 Phosphorylation

Researchers performed Affymetrix Gene Chip miRNA 4.0 microarray and observed differential regulation of miRNAs (75 upregulated and 199 downregulated) in metastatic MDA-MB-231 cells as compared to immortalized human non-tumorigenic breast epithelial cells.
[Scientific Reports]
Surapaneni, S. K., Bhat, Z. R., & Tikoo, K. (2020). MicroRNA-941 regulates the proliferation of breast cancer cells by altering histone H3 Ser 10 phosphorylation. Scientific Reports, 10(1), 17954. https://doi.org/10.1038/s41598-020-74847-7 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Consequences of Zmat3 Loss in c-MYC– and Mutant KRAS-Driven Tumorigenesis

To investigate which oncogenic drivers co-operate with Zmat3 loss to promote neoplastic transformation, researchers utilized Zmat3 knockout mice in models of c-MYC-driven lymphomagenesis and KrasG12D-driven lung adenocarcinoma development.
[Cell Death & Disease]
Full Article
Bookmark

No account yet? Register

0
Share

ROS-Mediated Genotoxic Stress Is Involved in NaAsO2-Induced Cell Cycle Arrest, Stemness Enhancement and Chemoresistance of Prostate Cancer Cells in a p53-Independent Manner

The authors suggest that ROS-mediated genotoxic stress is involved in NaAsO2-induced cell cycle arrest, stemness enhancement and chemoresistance of prostate cancer cells in a p53-independent manner.
[Ecotoxicology and Environmental Safety]
Zhang, Z.-H., Hong, Q., Zhang, Z.-C., Xing, W.-Y., Xu, S., Tian, Q.-X., Ye, Q.-L., Wang, H., Yu, D.-X., Xie, D.-D., & Xu, D.-X. (2021). ROS-mediated genotoxic stress is involved in NaAsO2-induced cell cycle arrest, stemness enhancement and chemoresistance of prostate cancer cells in a p53-independent manner. Ecotoxicology and Environmental Safety, 208, 111436. https://doi.org/10.1016/j.ecoenv.2020.111436 Cite
Abstract
Bookmark

No account yet? Register

0
Share

The Botanical Component p-Hydroxycinnamic Acid Suppresses the Growth and Bone Metastatic Activity of Human Prostate Cancer PC-3 Cells In Vitro

Scientists investigated the anticancer effects of botanical component p-hydroxycinnamic acid on the PC-3 cells in vitro model of bone metastatic human prostate cancer.
[Cancer Research]
Yamaguchi, M., Murata, T., & Ramos, J. W. (2020). The botanical component p-hydroxycinnamic acid suppresses the growth and bone metastatic activity of human prostate cancer PC-3 cells in vitro. Journal of Cancer Research and Clinical Oncology. https://doi.org/10.1007/s00432-020-03405-5 Cite
Abstract
Bookmark

No account yet? Register

0
Share

Introduction of hsa-MiR-512-3p as a New Regulator of HER2 Signaling Pathway in Breast Cancer

Researchers found that miR-512-3p acted as a cell-type-specific tumor suppressor, through targeting HER2, HER3, PIK3R2, and AKT1 transcripts.
[Breast Cancer Research and Treatment]
Mohamadzade, Z., Mahjoubi, F., & Soltani, B. M. (2020). Introduction of hsa-miR-512-3p as a new regulator of HER2 signaling pathway in breast cancer. Breast Cancer Research and Treatment. https://doi.org/10.1007/s10549-020-05937-3 Cite
Abstract
Bookmark

No account yet? Register

0
Share

LncRNA BCYRN1 Inhibits Glioma Tumorigenesis by Competitively Binding with miR-619-5p to Regulate CUEDC2 Expression and the PTEN/AKT/p21 Pathway

Three fresh tumor tissues from glioma patients and three normal brain tissues from craniocerebral trauma patients were prepared for high-throughput RNA sequencing.
[Oncogene]
Mu, M., Niu, W., Zhang, X., Hu, S., & Niu, C. (2020). LncRNA BCYRN1 inhibits glioma tumorigenesis by competitively binding with miR-619-5p to regulate CUEDC2 expression and the PTEN/AKT/p21 pathway. Oncogene, 1–14. https://doi.org/10.1038/s41388-020-01466-x Cite
Full Article
Bookmark

No account yet? Register

0
Share

LRP6 Downregulation Promotes Cardiomyocyte Proliferation and Heart Regeneration

Researchers investigated the role of lipoprotein receptor-related protein 6 (LRP6) in heart repair through regulation of cardiomyocyte proliferation. Lrp6 deficiency increased cardiomyocyte cell cycle activity in neonatal, juvenile and adult mice.
[Cell Research]
Full Article
Bookmark

No account yet? Register

0
Share

Oxidative Stress-Mediated Mitochondrial Dysfunction Facilitates Mesenchymal Stem Cell Senescence in Ankylosing Spondylitis

Researchers found that ankylosing spondylitis (AS) serum facilitated senescence of MSCs in vitro, and articular tissues from AS patients exhibited higher expression levels of the cell cycle arrest-related proteins p53, p21 and p16.
[Cell Death & Disease]
Ye, G., Xie, Z., Zeng, H., Wang, P., Li, J., Zheng, G., Wang, S., Cao, Q., Li, M., Liu, W., Cen, S., Li, Z., Wu, Y., Ye, Z., & Shen, H. (2020). Oxidative stress-mediated mitochondrial dysfunction facilitates mesenchymal stem cell senescence in ankylosing spondylitis. Cell Death & Disease, 11(9), 1–13. https://doi.org/10.1038/s41419-020-02993-x Cite
Full Article
Bookmark

No account yet? Register

0
Share

Poly(ADP-Ribose) Polymerase 1 (PARP1) Restrains MyoD-Dependent Gene Expression during Muscle Differentiation

The authors observed that Poly(ADP-ribose) Polymerase 1 (PARP1) depletion boosted the up-regulation of MyoD targets, such as p57, myogenin, Mef2C and p21, while its re-expression reverted this effect. They also found that PARP1 interacted with some MyoD-binding regions and that its presence, independently of the enzymatic activity, interfered with MyoD recruitment and gene induction.
[Scientific Reports]
Full Article
Bookmark

No account yet? Register

0
Share

Transcriptional Repression of p21 by EIF1AX Promotes the Proliferation of Breast Cancer Cells

A mechanistic investigation showed that EIF1AX inhibited the expression of p21, which is an essential cell cycle regulator.
[Cell Proliferation]
Li, Y., Guo, L., Ying, S., Feng, G.-H., & Zhang, Y. (n.d.). Transcriptional repression of p21 by EIF1AX promotes the proliferation of breast cancer cells. Cell Proliferation, n/a(n/a), e12903. https://doi.org/10.1111/cpr.12903 Cite
Full Article
Bookmark

No account yet? Register

0
Share

MicroRNA-107 Enhances Radiosensitivity by Suppressing Granulin in PC-3 Prostate Cancer Cells

Scientists found microRNA-107 enhanced radiosensitivity by regulating granulin in prostate cancer cells. MiR-107 was downregulated and granulin was upregulated in response to ionizing radiation in prostate cancer cells.
[Scientific Reports]
MicroRNA-107 enhances radiosensitivity by suppressing granulin in PC-3 prostate cancer cells | Scientific Reports. (n.d.). Retrieved September 3, 2020, from https://www.nature.com/articles/s41598-020-71128-1 Cite
Full Article
Bookmark

No account yet? Register

0
Share
Share