The authors found that exosomes derived from metastatic colorectal cancer (CRC) cell line SW620 promoted migration, invasion, and epithelial-mesenchymal transition of CRC cells.
[Molecular Therapy-Nucleic Acids]
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Sun, X., Lin, F., Sun, W., Zhu, W., Fang, D., Luo, L., Li, S., Zhang, W., & Jiang, L. (2021). Exosome-transmitted miRNA-335-5p promotes colorectal cancer invasion and metastasis by facilitating epithelial-mesenchymal transition via targeting RASA1. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2021.02.022 Cite
Researchers investigated the expression of ZNF674-AS1 in 83 pairs of NSCLC specimens and adjacent noncancerous lung tissues. The clinical significance of ZNF674-AS1 in NSCLC was analyzed. The role of ZNF674-AS1 in NSCLC growth and cell cycle progression was explored.
[Cellular & Molecular Biology Letters]
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The recovery of C2orf40 expression in hepatocellular carcinoma cell lines could induce G0/G1 phase arrest and apoptosis, and also inhibit cell migration and invasion by reversing the epithelial–mesenchymal transition process, both in vivo and in vitro.
[Journal of Gastroenterology and Hepatology]
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Wu, Y., Xiang, Q., Lv, X., Xiang, X., Feng, Z., Tian, S., Tang, J., Xiang, T., & Gong, J. (n.d.). C2orf40 inhibits hepatocellular carcinoma through UBR5-dependent or p53-independent mechanisms. Journal of Gastroenterology and Hepatology, n/a(n/a). https://doi.org/https://doi.org/10.1111/jgh.15441 Cite
Investigators demonstrated that nicotinamide phosphoribosyltransferase (NAMPT) is indispensable for the maintenance, survival, and hematopoietic differentiation of induced pluripotent stem cells.
[Stem Cell Research & Therapy]
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The authors investigated the potential of extracellular vesicles derived from human umbilical vein endothelial cells to transfer miR-203 to affect the progression of non-small cell lung cancer (NSCLC). miR-203 and p21 were poorly expressed while DTL was highly expressed both in NSCLC tissues and cell lines.
[Cancer Gene Therapy]
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The authors investigated the potential of extracellular vesicles derived from HUVECs to transfer miR-203 to affect the progression of non-small cell lung cancer.
[Cancer Gene Therapy]
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Scientists hypothesized that SHCBP1 and EOGT could mediate PDAC progression by influencing NOTCH1 O-GlcNAcylation.
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Yang, C., Hu, J.-F., Zhan, Q., Wang, Z.-W., Li, G., Pan, J.-J., Huang, L., Liao, C.-Y., Huang, Y., Tian, Y.-F., Shen, B.-Y., Chen, J.-Z., Wang, Y.-D., & Chen, S. (2021). SHCBP1 interacting with EOGT enhances O-GlcNAcylation of NOTCH1 and promotes the development of pancreatic cancer. Genomics. https://doi.org/10.1016/j.ygeno.2021.01.010 Cite
Investigators demonstrated that betalain was able to reduce the viability of A549 cells dose dependently with undetectable toxicity toward normal human cells.
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Scientists showed that albanol B inhibited the proliferation of four human lung cancer cell lines and induced apoptosis, based on the cleavage of caspase-7 and PARP, as well as the downregulation of Bcl-2.
[International Journal of Molecular Sciences]
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Scientists showed that compared with bone marrow-MSCs isolated from young and aged samples, NADH dehydrogenase iron-sulfur protein 6 (Ndufs6) was depressed in aged MSCs.
[Cell Death & Disease]
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Zhang, Y., Guo, L., Han, S., Chen, L., Li, C., Zhang, Z., Hong, Y., Zhang, X., Zhou, X., Jiang, D., Liang, X., Qiu, J., Zhang, J., Li, X., Zhong, S., Liao, C., Yan, B., Tse, H.-F., & Lian, Q. (2020). Adult mesenchymal stem cell ageing interplays with depressed mitochondrial Ndufs6. Cell Death & Disease, 11(12), 1–15. https://doi.org/10.1038/s41419-020-03289-w Cite
PAK4 knockout induced adhesion protein re-expression in endothelial cells, reduced vascular abnormalities, improved T cell infiltration and inhibits glioblastoma growth in mice.
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Ma, W., Wang, Y., Zhang, R., Yang, F., Zhang, D., Huang, M., Zhang, L., Dorsey, J. F., Binder, Z. A., O’Rourke, D. M., Fraietta, J. A., Gong, Y., & Fan, Y. (2020). Targeting PAK4 to reprogram the vascular microenvironment and improve CAR-T immunotherapy for glioblastoma. Nature Cancer, 1–15. https://doi.org/10.1038/s43018-020-00147-8 Cite