Lung Epithelial and Endothelial Damage, Loss of Tissue Repair, Inhibition of Fibrinolysis, and Cellular Senescence in Fatal COVID-19

Lung autopsy samples from 18 patients with fatal COVID-19, with symptom onset-to-death times ranging from 3 to 47 days, and antemortem plasma samples from 6 of these cases were evaluated using deep sequencing of SARS-CoV-2 RNA, multiplex plasma protein measurements, and pulmonary gene expression and imaging analyses.
[Science Translational Medicine]
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Novel Chemotherapeutic Agent FX-9 Activates NF-κB Signaling and Induces G1 Phase Arrest by Activating CDKN1A in a Human Prostate Cancer Cell Line

Investigators conducted microarray gene expression analysis and compared FX-9 exposed and unexposed prostate cancer cells, followed by pathway analysis and gene annotation to functional processes.
[BMC Cancer]
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IER2-Induced Senescence Drives Melanoma Invasion through Osteopontin

The authors observed coordinate expression of IER2, p53/p21, and osteopontin in primary human melanomas and metastases, which highlighted the pathophysiological relevance of IER2-mediated senescence in melanoma progression.
[Oncogene]
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Long Noncoding RNA p21 Enhances Autophagy to Alleviate Endothelial Progenitor Cells Damage and Promote Endothelial Repair in Hypertension through SESN2/AMPK/TSC2 Pathway

The authors showed that the number of endothelial progenitor cells (EPCs) in hypertensive patients was significantly lower than that of normal population, and the cell function decreased with a higher proportion of EPCs at later stages.
[Pharmacological Research]
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A cGAS-Dependent Response Links DNA Damage and Senescence in Alveolar Epithelial Cells: A Potential Drug Target in IPF

Scientists investigated the role of the DNA-sensing GMP-AMP synthase in idiopathic pulmonary fibrosis, with a focus on alveolar epithelial cell senescence.
[American Journal of Physiology-Lung Cellular and Molecular Physiology]
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TC10 Regulates Breast Cancer Invasion and Metastasis by Controlling Membrane Type-1 Matrix Metalloproteinase at Invadopodia

The authors demonstrated that TC10, a member of a Cdc42 subfamily of p21 small GTPases, regulated the membrane type 1 matrix metalloproteinase-driven extracellular matrix degradation at invadopodia.
[Communications Biology]
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Down-Regulation of lncRNA MEG3 Promotes Chronic Low Dose Cadmium Exposure-Induced Cell Transformation and Cancer Stem Cell-Like Property

The long non-coding RNA microarray analysis showed that the expression level of a tumor suppressive lncRNA maternally expressed 3 was significantly down-regulated in cadium-transformed cells, which was confirmed by further q-PCR analysis.
[Toxicology and Applied Pharmacology]
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Effect of Extracorporeal Shock Wave Therapy on Keratinocytes Derived from Human Hypertrophic Scars

Keratinocytes derived from hypertrophic scar tissue were cultured and expression of proliferation markers, activation markers, differentiation markers, apoptosis factors, and proliferation/differentiation regulators was investigated to compared with that of those in keratinocytes derived from normal skin tissue.
[Scientific Reports]
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Benzimidazoles Induce Concurrent Apoptosis and Pyroptosis of Human Glioblastoma Cells via Arresting Cell Cycle

By analyzing the hub genes of glioblastoma multiforme (GBM) via weighted gene co-expression network analysis of the cancer genome atlas dataset, and using the connectivity map platform for drug repurposing, scientists found that multiple azole compounds had potential anti-GBM activity.
[Acta Pharmacologica Sinica]
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A Transcription-Based Mechanism for Oncogenic β-Catenin-Induced Lethality in BRCA1/2-Deficient Cells

Investigators reported that activation of β-catenin, an oncogene of the WNT signaling pathway, inhibited proliferation of BRCA1/2-deficient cells.
[Nature Communications]
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Downregulation of TMEM220 Promotes Tumor Progression in Hepatocellular Carcinoma

Through overexpressing TMEM220 in hepatocellular carcinoma cell lines, scientists found that the proliferation of cancer cells was significantly slowed down and metastasis was significantly reduced.
[Cancer Gene Therapy]
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