p21

[Journal of Agricultural and Food Chemistry] Cucurbitacin E (CE) belongs to the triterpenoids and has received substantial attention for its antineoplastic property. The authors revealed that CE significantly induced cellular senescence in colorectal cancer cells.

[American Journal of Physiology-Lung Cellular and Molecular Physiology] Kinase inhibitor of IRE1α treatment increased the differentiation of Krt19CreERT2-lineage-traced damage-associated transient progenitors (DATPs) into type 1 alveolar epithelial cells after bleomycin injury, indicating that relief from IRE1α signaling enabled DATPs to exit the transitional state.

[Molecular Cancer therapeutics] Investigators characterized responses to olaparib in sensitive LNCaP and C4-2B cells and developed two olaparib resistant derivative cell line models from each. In LNCaP and C4-2B cells, they found that olaparib induced massive DNA damage, leading to activation of the G2/M checkpoint, activation of p53, and cell cycle arrest.

[Heliyon] Researchers investigated melatonin's antitumor molecular mechanisms to inhibit the proliferation of HepG2 cells.

[Molecular Neurodegeneration] The authors performed an integrative gene network analysis of bulk and single-cell RNA-seq data in non-diseased human tissues to investigate senescence gene co-expression signatures and their cell-type specificity.

[Translational Oncology] Researchers developed a new PAK4 inhibitor, PAKib and tested its effect on pancreatic cancer (PC) cell growth in vitro and in a syngeneic mouse model of PC.