p21

[American Journal of Physiology-Lung Cellular and Molecular Physiology] Scientists investigated the role of the DNA-sensing GMP-AMP synthase in idiopathic pulmonary fibrosis, with a focus on alveolar epithelial cell senescence.

[Toxicology and Applied Pharmacology] The long non-coding RNA microarray analysis showed that the expression level of a tumor suppressive lncRNA maternally expressed 3 was significantly down-regulated in cadium-transformed cells, which was confirmed by further q-PCR analysis.

[Scientific Reports] Keratinocytes derived from hypertrophic scar tissue were cultured and expression of proliferation markers, activation markers, differentiation markers, apoptosis factors, and proliferation/differentiation regulators was investigated to compared with that of those in keratinocytes derived from normal skin tissue.

[Acta Pharmacologica Sinica] By analyzing the hub genes of glioblastoma multiforme (GBM) via weighted gene co-expression network analysis of the cancer genome atlas dataset, and using the connectivity map platform for drug repurposing, scientists found that multiple azole compounds had potential anti-GBM activity.

[Nature Communications] Investigators reported that activation of β-catenin, an oncogene of the WNT signaling pathway, inhibited proliferation of BRCA1/2-deficient cells.

[Cancer Gene Therapy] Through overexpressing TMEM220 in hepatocellular carcinoma cell lines, scientists found that the proliferation of cancer cells was significantly slowed down and metastasis was significantly reduced.