p53

[Cell Death Discovery] Researchers discovered that TRAF7 was overexpressed in hepatocellular carcinoma tumor tissues and the increased TRAF7 expression was closely associated with tumor size, histologic grade, TNM stage and poor prognostication.

[Oxidative Medicine and Cellular Longevity] Scientists showed that UVB provoked apoptosis-associated speck-like protein (ASC) speck formation in human primary keratinocytes prior to cell death, and that specks were, opposed to the perinuclear cytosolic localization in myeloid cells, formed in the nucleus.

[Oncogene] Researchers reported that mammary epithelial-specific disruption of β1 integrin in a murine model of Luminal B human breast cancer drastically impaired tumor growth with proliferation block, apoptosis induction and cellular senescence.

[Cancer Letters] The authors address the noncanonical roles of p53 and their implications in sarcoma initiation and progression.

[Oncogenesis] Researchers sugggested that alpha thalassemia mental retardation X-linked (ATRX) maintained genome integrity and p53 deficiency attenuated replication stress-induced DNA damage in neuroblastoma cells featuring inactivated ATRX by regulating DNA repair mechanisms.

[Scientific Reports] Scientists showed that mice haploinsufficient for MDM2, a key regulator of p53, in their adipose stores suffered from overt obesity, glucose intolerance, and hepatic steatosis.