Divergent Roles of PI3K Isoforms in PTEN-Deficient Glioblastomas

Researchers showed that PTEN-deficient glioblastomas largely depended on p110α for proliferation and p110β for migration.
[Cell Reports]
Xie, S., Ni, J., McFaline-Figueroa, J. R., Wang, Y., Bronson, R. T., Ligon, K. L., Wen, P. Y., Roberts, T. M., & Zhao, J. J. (2020). Divergent Roles of PI3K Isoforms in PTEN-Deficient Glioblastomas. Cell Reports, 32(13). https://doi.org/10.1016/j.celrep.2020.108196 Cite
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MYC Promotes Bone Marrow Stem Cell Dysfunction in Fanconi Anemia

To identify determinants of bone marrow failure, researchers performed single-cell transcriptome profiling of primary hematopoietic stem and progenitor cells from Fanconi anemia patients.
[Cell Stem Cell]
Rodríguez, A., Zhang, K., Färkkilä, A., Filiatrault, J., Yang, C., Velázquez, M., Furutani, E., Goldman, D. C., Teresa, B. G. de, Garza-Mayén, G., McQueen, K., Sambel, L. A., Molina, B., Torres, L., González, M., Vadillo, E., Pelayo, R., Fleming, W. H., Grompe, M., … D’Andrea, A. D. (2020). MYC Promotes Bone Marrow Stem Cell Dysfunction in Fanconi Anemia. Cell Stem Cell, 0(0). https://doi.org/10.1016/j.stem.2020.09.004 Cite
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Matrix Metalloprotease-7 Mediates Nucleolar Assembly & Intra-Nucleolar Cleaving p53 in Gefitinib Resistant Cancer Stem Cells

Researchers showed that matrix metalloproteinase-7 shedding MUC-1 SEA domain releases MUC-1 C-ter facilitating the nucleolus trafficking of p53 in gefitinib-resistant lung cancer stem cells.
[iScience]
Yu, W.-H., Wu, E., Li, Y., Hou, H.-H., Yu, S. C., Huang, P.-T., Kuo, W.-H., Qi, D., & Yu, C.-J. (2020). Matrix metalloprotease-7 mediates nucleolar assembly & intra-nucleolar cleaving p53 in gefitinib resistant cancer stem cells. IScience, 0(0). https://doi.org/10.1016/j.isci.2020.101600 Cite
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Introduction of hsa-MiR-512-3p as a New Regulator of HER2 Signaling Pathway in Breast Cancer

Researchers found that miR-512-3p acted as a cell-type-specific tumor suppressor, through targeting HER2, HER3, PIK3R2, and AKT1 transcripts.
[Breast Cancer Research and Treatment]
Mohamadzade, Z., Mahjoubi, F., & Soltani, B. M. (2020). Introduction of hsa-miR-512-3p as a new regulator of HER2 signaling pathway in breast cancer. Breast Cancer Research and Treatment. https://doi.org/10.1007/s10549-020-05937-3 Cite
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The Role of Autophagy in Targeted Therapy for Acute Myeloid Leukemia

Scientists review studies on the role of autophagy in acute myeloid leukemia (AML) development and summarize the linkage between autophagy and several recurrent genetic abnormalities in AML, highlighting the potential of capitalizing on autophagy modulation in targeted therapy for AML.
[Autophagy]
Du, W., Xu, A., Huang, Y., Cao, J., Zhu, H., Yang, B., Shao, X., He, Q., & Ying, M. (2020). The role of autophagy in targeted therapy for acute myeloid leukemia. Autophagy, 0(0), 1–15. https://doi.org/10.1080/15548627.2020.1822628 Cite
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Matrix Metalloprotease-7 Mediates Nucleolar Assembly & Intra-Nucleolar Cleaving p53 in Gefitinib Resistant Cancer Stem Cells

Investigators showed that matrix metalloproteinase-7 shedding MUC-1 SEA domain releases MUC-1 C-ter facilitating the nucleolus trafficking of p53 in gefitinib-resistant lung cancer stem cells.
[iScience]
Yu, W.-H., Wu, E., Li, Y., Hou, H.-H., Yu, S. C., Huang, P.-T., Kuo, W.-H., Qi, D., & Yu, C.-J. (2020). Matrix metalloprotease-7 mediates nucleolar assembly & intra-nucleolar cleaving p53 in gefitinib resistant cancer stem cells. IScience, 0(0). https://doi.org/10.1016/j.isci.2020.101600 Cite
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The Role of Autophagy in Targeted Therapy for Acute Myeloid Leukemia

Scientists review studies on the role of autophagy in acute myeloid leukemia (AML) development and summarize the linkage between autophagy and several recurrent genetic abnormalities in AML, highlighting the potential of capitalizing on autophagy modulation in targeted therapy for AML.
[Autophagy]
Du, W., Xu, A., Huang, Y., Cao, J., Zhu, H., Yang, B., Shao, X., He, Q., & Ying, M. (2020). The role of autophagy in targeted therapy for acute myeloid leukemia. Autophagy, 0(0), 1–15. https://doi.org/10.1080/15548627.2020.1822628 Cite
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CB11, a Novel Purine-Based PPARɣ Ligand, Overcomes Radio-Resistance by Regulating ATM Signaling and EMT in Human Non-Small-Cell Lung Cancer Cells

CB11 caused cell death via reactive oxygen species-mediated ATM-p53-GADD45α signaling in human non-small-cell lung cancer cells, and diphenyleneiodonium, an NADPH oxidase inhibitor, decreases cell death by inhibiting CB11-mediated ATM signaling.
[British Journal of Cancer]
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Oxidative Stress-Mediated Mitochondrial Dysfunction Facilitates Mesenchymal Stem Cell Senescence in Ankylosing Spondylitis

Researchers found that ankylosing spondylitis (AS) serum facilitated senescence of MSCs in vitro, and articular tissues from AS patients exhibited higher expression levels of the cell cycle arrest-related proteins p53, p21 and p16.
[Cell Death & Disease]
Ye, G., Xie, Z., Zeng, H., Wang, P., Li, J., Zheng, G., Wang, S., Cao, Q., Li, M., Liu, W., Cen, S., Li, Z., Wu, Y., Ye, Z., & Shen, H. (2020). Oxidative stress-mediated mitochondrial dysfunction facilitates mesenchymal stem cell senescence in ankylosing spondylitis. Cell Death & Disease, 11(9), 1–13. https://doi.org/10.1038/s41419-020-02993-x Cite
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DNA Methylation across the Genome in Aged Human Skeletal Muscle Tissue and Muscle-Derived Cells: The Role of HOX Genes and Physical Activity

Using 850K DNA methylation arrays researchers compared the methylomes of young and aged human skeletal muscle and that of young/aged heterogenous muscle-derived human primary cells over several time points of differentiation.
[Scientific Reports]
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A Phospho-Switch Controls RNF43-Mediated Degradation of Wnt Receptors to Suppress Tumorigenesis

The authors demonstrated that RNF43 mutations cooperated with KRAS mutations to promote multi-step tumorigenesis via the Wnt-Ras-p53 axis in human colon cancers. Phosphomimetic substitutions of the serine trio restored the tumour suppressive activity of extracellular oncogenic mutants.
[Nature Communications]
A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis | Nature Communications. (n.d.). Retrieved September 18, 2020, from https://www.nature.com/articles/s41467-020-18257-3# Cite
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