p53

[Scientific Reports] Gene knockout studies revealed that SOX2 was an essential factor for the generation of CSCs by HRASV12 in mouse and human fibroblasts.

[Molecular Therapy Oncolytics] The combination of reovirus and NAD+ depletion achieved greater antitumor effects in KMS12 tumors in vivo and patient-derived CD138+ multiple myeloma cells.

[European Journal of Pharmacology] The authors discuss the therapeutic potential of p53-reactivating compounds with a particular focus on the pharmacological rescue of p53 in metastatic prostate cancer.

[Cell Death & Disease] Investigators reported that RNF187, a RING family ubiquitin ligase, facilitated breast cancer growth and inhibited apoptosis by modulating P53 signaling.

[Journal of Dermatological Science] Researchers investigated whether miR-155 regulated glycolysis of psoriasis and the underlying mechanisms. Human dermal-derived MSCs were treated with miR-155 mimic or inhibitor, followed by assessments of cells proliferation, metabolism and inflammatory response.

[Molecular Biology Reports] Researchers assessed the suppressing effect of VGB4, a vascular endothelial growth factor (VEGF) antagonist peptide with the binding ability to both VEGF receptor1 and VEGF receptor2, on VEGF-induced proliferation and migration of the human lung adenocarcinoma cell line A549 and the human colon adenocarcinoma cell line HT29.