Ascentage Pharma Announces First Patient Dosed in the Phase Ib Study of MDM2-p53 Inhibitor APG-115 as Single Agent and in Combinations for the Treatment of Hematologic Malignancies in China

Ascentage Pharma announced that the Phase Ib study of the company’s novel MDM2-p53 inhibitor candidate APG-115 as a single agent or in combinations for the treatment of Chinese patients with relapsed/refractory acute myeloid leukemia, or relapsed/progressed high/very high risk myelodysplastic syndrome has dosed its first patient in China.
[Ascentage Pharma]
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Emerging Role of FBXO22 in Carcinogenesis

Scientists summarize the regulatory factors and downstream targets of FBXO22 in cancers, discuss its functions in tumorigenesis, and further highlight the alteration of FBXO22 expression in a variety of human malignancies.
[Cell Death Discovery]
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Regulation of MYO18B mRNA by a Network of C19MC miRNA-520G, Ifn-γ, Cebpb, p53 and bFGF in Hepatocellular Carcinoma

Researchers identified a network of positive and negative regulators of MYO18B mRNA expression which reflects the survival of hepatocellular carcinoma patients.
[Scientific Reports]
Jinesh, G. G., Napoli, M., Ackerman, H. D., Raulji, P. M., Montey, N., Flores, E. R., & Brohl, A. S. (2020). Regulation of MYO18B mRNA by a network of C19MC miRNA-520G, IFN-γ, CEBPB, p53 and bFGF in hepatocellular carcinoma. Scientific Reports, 10(1), 12371. https://doi.org/10.1038/s41598-020-69179-5 Cite
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SOX2 and p53 Expression Control Converges in PI3K/AKT Signaling with Versatile Implications for Stemness and Cancer

The authors summarize the latest advances in the understanding of PI3K/AKT/SOX2-driven stemness and its intertwined relations to p53-signaling in DNA damage response under conditions of pluripotency, reprogramming, and transformation.
[International Journal of Molecular Sciences]
Schaefer, T., Steiner, R., & Lengerke, C. (2020). SOX2 and p53 Expression Control Converges in PI3K/AKT Signaling with Versatile Implications for Stemness and Cancer. International Journal of Molecular Sciences, 21(14), 4902. https://doi.org/10.3390/ijms21144902 Cite
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Aprea Therapeutics Announces Expansion of Clinical Trial Evaluating Eprenetapopt for the Front-Line Treatment of TP53 Mutant Acute Myeloid Leukemia (AML)

Aprea Therapeutics, Inc. announced the expansion of patient enrollment in its Phase I clinical trial evaluating eprenetapopt in TP53 mutant AML.
[Aprea Therapeutics, Inc.]
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Radiogenomics for Predicting p53 Status, PD-L1 Expression, and Prognosis with Machine Learning in Pancreatic Cancer

107 patients diagnosed with pancreatic ductal adenocarcinoma were retrospectively examined. The relationship between p53 mutations as well as PD-L1 abnormal expression and clinicopathological factors was investigated using immunohistochemistry.
[British Journal of Cancer]
Iwatate, Y., Hoshino, I., Yokota, H., Ishige, F., Itami, M., Mori, Y., Chiba, S., Arimitsu, H., Yanagibashi, H., Nagase, H., & Takayama, W. (2020). Radiogenomics for predicting p53 status, PD-L1 expression, and prognosis with machine learning in pancreatic cancer. British Journal of Cancer, 1–9. https://doi.org/10.1038/s41416-020-0997-1 Cite
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Radiation Response of Murine Embryonic Stem Cells

To understand the mechanisms of disturbed differentiation and development by radiation, murine CGR8 embryonic stem cells were exposed to ionizing radiation and differentiated by forming embryoid bodies.
[Cells]
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Inactivating p53 Is Essential for Nerve Growth Factor Receptor to Promote Melanoma-Initiating Cell-Stemmed Tumorigenesis

Researchers report that a feedback inhibition of p53 by nerve growth factor receptor played an essential role in maintaining the sphere formation and proliferation of melanoma-initiating cells (MICs), and in promoting MIC-derived melanoma growth in vivo.
[Cell Death & Disease]
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The Role of MDM2–p53 Axis Dysfunction in the Hepatocellular Carcinoma Transformation

The authors focus on the current studies of the MDM2–p53 axis in hepatocellular carcinoma, and specifically discuss the impact of MDM2–p53 axis dysfunction by viral infection and metabolic disease in the transformation of normal hepatocytes into hepatoma cells.
[Cell Death Discovery]
The role of MDM2–p53 axis dysfunction in the hepatocellular carcinoma transformation | Cell Death Discovery. (n.d.). Retrieved June 23, 2020, from https://www.nature.com/articles/s41420-020-0287-y Cite
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Lineage Reversion Drives WNT Independence in Intestinal Cancer

Scientists showed that while WNT suppression blocked tumor growth in most organoid and in vivo colorectal cancer (CRC) models, the accumulation of CRC-associated genetic alterations enabled drug resistance and WNT-independent growth.
[Cancer Discovery]
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