Tag results:
p65
Immune Regulation News
METTL3 Overexpression Aggravates LPS-Induced Cellular Inflammation in Mouse Intestinal Epithelial Cells and DSS-Induced IBD in Mice
[Cell Death Discovery] Within LPS-treated MODE-K cells, METTL3 knockdown promoted cell viability, inhibited cell apoptosis, decreased apoptotic caspase3/9 cleavage, and decreased the levels of proinflammatory cytokines and inflammatory enzymes
Extracellular Matrix News
The KDM6A-SPARCL1 Axis Blocks Metastasis and Regulates the Tumor Microenvironment of Gastrointestinal Stromal Tumors by Inhibiting the Nuclear Translocation of p65
[British Journal of Cancer] KDM6A promoted the transcription of SPARCL1 by demethylating histone H3 lysine trimethylation and consequently led to the inactivation of p65. SPARCL1 affected the metastasis of gastrointestinal stromal tumor cells in a mesenchymal-epithelial transition- and matrix-metalloproteinase-dependent manner.
Pulmonary Cell News
Nuclear Factor-Kappa B (NF-κB) Inhibition as a Therapeutic Target for Plant Nutraceuticals in Mitigating Inflammatory Lung Diseases
[Chemico-Biological interactions] Scientists discuss the medical value of nutraceuticals briefly and their ability to mitigate various inflammatory lung diseases through targeting inhibition of NF-κB.
Muscle Cell News
Intrinsic Cardiac Adrenergic Cells Contribute to LPS-Induced Myocardial Dysfunction
[Communications Biology] Researchers showed that norepinephrine secretion from intrinsic cardiac adrenergic cells was increased through activation of Toll-like receptor 4 to aggravate myocardial TNF-α production and dysfunction by lipopolysaccharide (LPS).
Endothelial Cell News
Dapagliflozin Exerts Anti-inflammatory Effects via Inhibition of LPS-Induced TLR-4 Overexpression and NF-κB Activation in Human Endothelial Cells and Differentiated Macrophages
[European Journal of Pharmacology] The authors assessed the direct anti-inflammatory effects of sodium-glucose co-transporter 2 inhibitors dapagliflozin on two cell types involved in the process of atherogenesis.
Pancreatic Cell News
FGD3 Binds with HSF4 to Suppress p65 Expression and Inhibit Pancreatic Cancer Progression
[Oncogene] FGD3, which is involved in regulating the actin cytoskeleton and cell shape, has been reported to inhibit cancer cell migration and predict a favorable prognosis in multiple types of cancer. Researchers conducted a systematic investigation of the cancer-related role of FGD3 in pancreatic cancer.