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p65

Upregulation of CPNE7 in Mesenchymal Stromal Cells Promotes Oral Squamous Cell Carcinoma Metastasis through the NF-κB Pathway

[Cell Death Discovery] Scientists demonstrated that MSCs derived from oral squamous cell carcinoma (OSCC) promoted the metastasis of OSCC cells by transwell assay and animal models through epithelial to mesenchymal transition.

Extracellular Vesicles Secreted from Mesenchymal Stem Cells Exert Anti-Apoptotic and Anti-Inflammatory Effects via Transmitting microRNA-18b in Rats with Diabetic Retinopathy

[International Immunopharmacology] Scientists investigated the anti-inflammatory properties of small extracellular vesicles derived from human umbilical cord MSCs in a diabetic rat model and human retinal microvascular endothelial cells.

A20 Controls Expression of Beta-Cell Regulatory Genes and Transcription Factors

[Journal of Molecular Endocrinology] Scientists investigated the mechanisms underlying the protective role of A20 in the pancreatic beta-cell. Investigators demonstrated a role for A20 in controling beta-cell integrity and survival, which likely resulted from the regulation of inflammatory signaling

MRTF-a-NF-κB/p65 Axis-Mediated PDL1 Transcription and Expression Contributes to Immune Evasion of Non-Small-Cell Lung Cancer via TGF-β

[Experimental and Molecular Medicine] Researchers defined a new signaling pathway that regulated the transcription and expression of PD-L1 upon TGF-β treatment, which might have a significant impact on research into the application of immunotherapy in treating lung cancer.

An Additional NF-κB Site Allows HIV-1 Subtype C to Evade Restriction by Nuclear PYHIN Proteins

[Cell Reports] Scientists demonstrated that a characteristic additional third nuclear factor κB binding site in the long terminal repeat promoter allows subtype C HIV-1 strains to evade restriction by nuclear PYHIN proteins.

Exosomal Micro‐RNA‐96 Derived From Bone Marrow Mesenchymal Stem Cells Inhibits Doxorubicin‐Induced Myocardial Toxicity by Inhibiting the Rac1/Nuclear Factor‐κB Signaling Pathway

[Journal of the American Heart Association] Researchers investigated the functional mechanism of exosomal microRNA‐96 derived from bone marrow mesenchymal stem cells in myocardial toxicity induced by doxorubicin.

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