pancreatic cancer cells

[Scientific Reports] Investigators assessed the anti-tumor effects of probiotic bacteria against pancreatic cancer cells. Among the known probiotic bacteria, Aspergillus oryzae exhibited a strong pancreatic tumor suppression effect.

[Proceedings of the National Academy of Sciences of the United States of America] Investigators used proximity labeling to identify protein interactors of active KRAS in pancreatic ductal adenocarcinoma (PDAC) cells. We expressed fusions of wild-type (WT) (BirA-KRAS4B), mutant (BirA-KRAS4BG12D), and nontransforming cytosolic double mutant (BirA-KRAS4BG12D/C185S) KRAS with the BirA biotin ligase in murine PDAC cells.

[Pharmacological Research] Glycogen synthase kinase-3 β (GSK3β) was identified as a downstream target of PFKFB4 and an PFKFB4-interacting protein.

[Scientific Reports] Investigators found that the histone acetyltransferases inhibitor C646 augmented anti-tumor effects in vitro by inhibiting cell proliferation and cell cycle progression concomitantly with suppression of acetylated H3K9 and H3K27 expression.

[DNA and Cell Biology] In vitro functional experiments showed that LINC00173 overexpression inhibited the proliferation and invasion of pancr

[Scientific Reports] Scientists presented the design and synthesis of a small library of substituted biguanidium salts and their capacity to inhibit the growth of pancreatic cancer cells.