pancreatic cancer cells

[Oncogene] Scientists performed the molecular and histological assessment of patient-derived PanINs, tumor tissues and pancreas from mouse models with PDAC, where they noted marked upregulation of gastrokine proteins.

[Science Advances] Nontransformed cells in tumors can help cancer cells overcome metabolic limitations, particularly in pancreatic cancer, where pancreatic stellate cells (PSCs) promote cancer cell proliferation and tumor growth.

[Medical Oncology] Researchers employed a co-culture system to clarify the effects of human amniotic mesenchymal stromal cells secretome through tyrosine phosphorylation of c-Src, SGK223, AKT activity, and JAK1/Stat3 signaling in Panc1 pancreatic cancer cells.

[Cell Communication and Signaling] In pancreatic cancer, exosomes are enriched with multiple signaling molecules that mediate intercellular communication with control of immune suppression, mutual promotion between pancreas stellate cells and pancreatic cancer cells, and reprogramming of normal cells.

[Oncogene] FGD3, which is involved in regulating the actin cytoskeleton and cell shape, has been reported to inhibit cancer cell migration and predict a favorable prognosis in multiple types of cancer. Researchers conducted a systematic investigation of the cancer-related role of FGD3 in pancreatic cancer.

[Journal of Cancer] Scientists investigate the expression of hsa_circ_0074298 and the molecular mechanism that promoted tumor growth and enhanced the chemoresistance of pancreatic cancer.