pancreatic cancer cells

[Proceedings of the National Academy of Sciences of the United States of America] Researchers showed that the phosphatidylserine (PtdSer) lipid transport proteins, ORP5 and ORP8, which are essential for maintaining plasma membrane (PM) PtdSer levels and hence KRAS PM localization, were required for KRAS oncogenesis.

[Cancer Cell International] Investigators characterized the function of eukaryotic translation initiation factors (eIFs) in epithelial-mesenchymal-transition (EMT) and metastasis in pancreatic cancer cells to investigate whether eIFs and downstream c-MYC affect EMT and metastasis by joint interference.

[Proceedings of the National Academy of Sciences of the United States of America] The authors showed that SSEA-4 was more expressed in all pancreatic cancer cell lines examined but not detectable in normal pancreatic cells.

[Aging] The tumor-suppressive effects of puerarin were determined by both in vitro and in vivo assays. The effects of puerarin on the proliferation, apoptosis, migration and invasion of pancreatic cancer cells, and tumor growth and metastasis in pancreatic ductal adenocarcinoma xenograft mouse model were performed.

[Nature Communications] Scientists demonstrated a previously undescribed tumor cell-intrinsic role for glucocorticoid receptor (GR) in activating PD-L1 expression and repressing the major histocompatibility complex class I expression in pancreatic ductal adenocarcinoma cells through transcriptional regulation.

[Clinical and Translational Oncology] Researchers investigated the effects of exosomes extracted from human umbilical cord mesenchymal stem cells carrying hsa-miRNA-128-3p on pancreatic cancer cells.