pancreatic cancer cells

[Oncogene] Researchers identified MLK3 as a direct downstream target of MAP4K4. The MAP4K4 and MLK3 associated with each other, and MAP4K4 phosphorylates MLK3 on Thr738 and increased MLK3 kinase activity and downstream signaling.

[Journal of Experimental & Clinical Cancer Research] Kaplan–Meier plotter was used to analyze the prognostic significance of each of the all-known receptor tyrosine kinases to date in immune “hot” and “cold” pancreatic cancers.

[Cancer Gene Therapy] Cell counting kit-8 assay and colony formation assay were used to measure the proliferation of pancreatic cancer cells. RNA immunoprecipitation and Western blot were employed for investigation the binding between circPTPN22 and STAT3.

[Journal of Translational Medicine] Researchers identified key genes and pathways in the development of pancreatic cancer and provide targets for the treatment of pancreatic cancer.

[Cancer Science] The effects of gene therapy using small interfering RNA and short hairpin RNA (shRNA) for acid ceramidase inhibition with its mechanisms for pancreatic cancer were investigated.

[Acta Pharmacologica Sinica] Scientists showed that when the two receptors were co-expressed in HEK 293T cells with comparable receptor ratio to pancreatic cancer cells, glucose-dependent insulinotropic polypeptide (GIP) predominately induced cAMP accumulation while Glucagon-like peptide-1 (GLP-1) was biased towards β-arrestin 2 recruitment.