pancreatic cancer

[Small] It was observed that poly(2-oxazoline)-based polymeric micelles could be elongated over time from a spherical structure to worm-like structure, with elongation influenced by several conditions, including the amount and type of drug loaded into the micelles.

[Basic & Clinical Pharmacology & Toxicology] MLKL inhibitor NSA attenuated the killing effect of IMB5036 on pancreatic cancer cells. IMB5036 stimulated translocation of MLKL and p-MLKL from cytoplasm to cell membrane.

[Cell Communication and Signaling] Pancreatic ductal adenocarcinoma is not sensitive to monotherapy with immune checkpoint inhibitors, which might be related to the inhibitory immune microenvironment of pancreatic cancer.

[British Journal of Cancer] Researchers analyzed the alteration of collagen and gene expression profiles in pancreatic cancer tissues after NAT. Additionally, we examined the biological role of Ephrin-A5 using primary cultured cancer-associated fibroblasts (CAFs).

[Cancer Science] Investigators ectopically expressed α1,4-N-acetylglucosaminyltransferase (α4GnT), the α1,4-linked N-acetylglucosamine biosynthetic enzyme, together with MUC6 in the human pancreatic cancer cell lines MIA PaCa-2 and PANC-1, neither of which expressed α4GnT and MUC6.

[Journal For Immunotherapy of Cancer] Autologous tumor organoids were stimulated with T cells from the patients’ peripheral blood for two weeks to generate the organoid-primed T cells.