pancreatic cancer

[Cell Death & Disease] The biological effects of nuclear receptor subfamily 2 group F member 1 antisense RNA 1 (NR2F1-AS1) and NR2F1 in pancreatic cancer were investigated by in vitro and in vivo experiments.

[Cell Death & Disease] Scientists demonstrated that autophagy-associated circular RNAs (circRNA) circ-autophagy related 7 (circATG7) was elevated in pancreatic cancer (PC) tissues compared to adjacent tissues.

[Cell Death & Disease] Investigators reported that USP49 stability was governed by F-box protein 45 (Fbxo45)-mediated ubiquitination and was enhanced by the absence of Fbxo45.

[Cellular and Molecular Life Sciences] Transcriptional co-activator with PDZ-binding motif (TAZ) defect caused structural changes in the pancreas, particularly islet cell shrinkage, and decreased insulin production and β-cell markers expression, leading to hyperglycemia.

[Pathology Research and Practice] Scientists investigated the role of long coding RNA HOXD cluster antisense RNA 1 (HOXD-AS1) in pancreatic cancer and its underlying mechanisms.

[NPJ Genomic Medicine] Investigators identified a recurrent mutation at position c.28 in the gene encoding the snRNA U2. This mutation was present in B cell derived tumors, as well as in prostate and pancreatic cancer, suggesting U2 c.28 constitutes a driver candidate associated with worse prognosis.