pancreatic cells

[Phytotherapy Research] Investigators explored the function of lucidone in tumor cytotoxicity and chemosensitivity through the suppression of receptor for advanced glycation end products-initiated signaling in pancreatic ductal adenocarcinoma cells.

[Nature Metabolism] Scientists provided a single-cell atlas of pancreatic islets of 24 type 1 diabetes, autoantibody-positive and nondiabetic organ donors across multiple quantitative modalities including ~80,000 cells using single-cell transcriptomics, ~7,000,000 cells using cytometry by time of flight and ~1,000,000 cells using in situ imaging mass cytometry.

[European Journal of Pharmaceutical Sciences] Once the main hurdles to stem cell-based therapies are overcome, translation to clinical practice will greatly improve the quality of life of people with type 1 diabetes mellitus.

[Scientific Reports] Scientists established a novel method to generate CSCs from iPSCs under a cancerous microenvironment mimicked by the conditioned medium of cancer-derived cells.

[Angewandte Chemie-International Edition] Scientists generated 15 g of the tricyclic intermediate in 8 steps from ( R )-limonene and 720 mg of the penultimate bioactive intermediate in a protecting-group-free manner.

[Ecotoxicology and Environmental Safety] Researchers described a novel computational method for characterizing toxicity, associated biological perturbations and disease outcome, called the Chemo-Phenotypic Based Toxicity Measurement. The method was validated in the in vitro, in vivo and organoid models.