pancreatic cells

[Experimental and Molecular Medicine] Using a cell culture system of NIT-1, an islet β cell line, scientists found that increased small ubiquitin-like modifier (SUMO) 2/3 conjugation to DRP1 due to SUMO-specific protease 2 (SENP2) deficiency suppressed the phosphorylation of DRP1, which possibly induced mitochondrial dysfunction.

[Molecular Therapy] Scientists showed that microRNA-26a inhibited pancreatic acinar cell store-operated Ca2+ entry channel expression, Ca2+ overload, and acute pancreatitis.

[International Journal of Biological Macromolecules] Researchers investigated systematically the roles of a proteoglycan from Ganoderma lucidum in protection and repair of pancreatic β-cells against oxidative stress-induced injury and apoptosis on molecular, cellular and animal basis.

[Peptides] Scientists review the mechanistic underpinnings of urocortin 3 signaling, its net effect on islet cell hormone output, as well as its value as a marker for beta cell maturation and functional status.

[Medical Oncology] Researchers employed a co-culture system to clarify the effects of human amniotic mesenchymal stromal cells secretome through tyrosine phosphorylation of c-Src, SGK223, AKT activity, and JAK1/Stat3 signaling in Panc1 pancreatic cancer cells.

[Diabetes] Scientists assessed the global protein and individual protein tyrosine phosphatases (PTP) profiles in the pancreas from early onset non-obese diabetic mice treated with an anti-CD3 monoclonal antibody and interleukin-1 receptor antagonist.