pancreatic cells

[Scientific Reports] Investigators elucidated whether regulation of growth hormone secretagogue receptor-1a (GHS-R1a), one of the ghrelin receptors, improved the therapeutic effects of islet transplantation using [D-Lys3]-GHRP-6, a specific GHS-R1a antagonist.

[Aaps Pharmscitech] Therapeutic efficacy of antineoplastic agents possessing a selective target to the nucleus of the cancer cells could be enhanced through novel formulation approaches. Scientists showed that optimized formula enhanced cytotoxicity and apoptotic potential, compared with icariin (ICA)-raw, against pancreatic cancer cell lines.

[Cell Biology and Toxicology] Constitutive activation of NF-κB is frequently observed in pancreatic ductal adenocarcinoma (PDAC). Scientists found that YEATS2, a scaffolding protein of ATAC complex, was highly expressed in human PDAC.

[Islets] Aiming to contribute to a better understanding of the relationship between structural and functional properties of pancreatic islets, researchers reconstructed human and mice islets in order to perform a structural comparison based on both morphologic and network-derived metrics.

[Experimental & Molecular Medicine] Correlations of KLF10 deficiency with rapid metastasis, elevated EMT, and glycolysis were demonstrated in resected pancreatic adenocarcinoma tissues, in vitro assays, and murine models.

[NPJ Regenerative Medicine] Investigators show that store-dependent Ca2+ entry was essential for modulating the function of bone marrow-derived MSCs.