pancreatic cells

[Biochemical Genetics] Investigators explored the role of long-noncoding RNA nuclear paraspeckle assembly transcript 1 (NEAT1) in acute pancreatitis that was induced by caerulein in rat pancreatic acinar cells AR42J.

[Journal of Biochemical and Molecular Toxicology] Scientists delineated the role of gymnemic acid in protecting pancreatic β-cells in diabetic animals, with special reference to inflammation and apoptosis.

[Acta Pharmacologica Sinica] Two pan-KRAS inhibitors, BI-2852 and BAY-293, were chosen as chemical probes to investigate their antitumor potency in PDAC.

[Acta Diabetologica] CCK8, Ki67 staining, immunohistochemical analyses, glucose-stimulated insulin secretion and intraperitoneal glucose tolerance test were performed to detect the effect of Kcnq1ot1 on β-cell proliferation and insulin secretion in vitro and in vivo.

[International Journal of Oncology] It was demonstrated that COUP‑TFII_V2 naturally occured in PDAC cells and in primary samples, where its expression was consistent with shorter overall survival and peripheral invasion.

[Inflammation Research] Scientists demonstrated the protective role of Insulin-like growth factor 1 (IGF-1) against pancreatic β cell dysfunction and to probe into the underlying mechanisms.