pancreatic cells

[Biochemical Society Transactions] Proteolytic shedding of multiple protein ectodomains by matrix metalloproteinase 7 (MMP-7) from pancreatic cancer cell surfaces influence apoptosis, proliferation, migration, and invasion.

[The Lundquist Institute (Cision US, Inc.)] The Lundquist Institute's investigator Dr. Eiji Yoshihara has received a five-year $749,995.50 Career Development Award from the Juvenile Diabetes Research Foundation for his proposed study on how human β cells gain immune evasive function by environmental cues.

[Communications Biology] To discriminate the role of PFKFB3 from HIF1α in vivo, scientists generated mice with conditional β-cell specific disruption of the Pfkfb3 gene on a human islet pancreatic polypeptide background and a high-fat diet.

[Diabetologia] Mouse lines that expressed a gain-of-function mutation in the γ1 AMP-activated protein kinase (AMPK) subunit D316a were generated to examine the effects of chronic AMPK stimulation in the whole body, or selectively in the beta cell.

[Immunologic Research] In this current study, the authors discovered that epidermal growth factor receptor affected major histocompatibility complex class I mRNA and protein expression by human pancreatic cancer cell lines.

[iScience] Scientists showed that intracellular Ca2+ and reactive oxygen species signals generated by high glucose and cytokine-induced endoplasmic reticulum stress activated calcineurin/NFATc2 and PI3K/AKT to maintain β-cell identity and function.