pancreatic cells

[Molecular Metabolism] Researchers introduced SNAPf-tag into the N-terminal segment of GPR56 to enable monitoring of GPR56 cellular activity in situ.

[Chemistry & Biodiversity] Geranyl-2,4-dihydroxy-6-phenethylbenzoate (GDP), isolated from Boesenbergia pandurata rhizomes, exhibited potent preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrition starvation conditions.

[Journal of Molecular Endocrinology] Scientists found that an evolutionarily conserved region located approximately 40 kbp downstream of the transcription start site of Slc2a2 functioned as an active enhancer in the MIN6 β-cell line.

[Journal of Molecular Endocrinology] Researchers investigated the mechanism of dexamethasone-induced pancreatic β-cell apoptosis through the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) pathway in cultured cells and isolated mouse islets.

[International Journal of Oncology] Researchers detected the expression of interleukin‑28 receptor α subunit (IL‑28RA) in PDAC tissues using immunofluorescence staining and western blotting.

[Science Advances] Scientists genetically engineered MSCs with Exendin-4, a glucagon-like peptide-1 analog, and demonstrated their boosted cellular functions and antidiabetic efficacy in a type 2 diabetes mellitus mouse model.