pancreatic cells

[Acta Pharmacologica Sinica] Researchers demonstrated that the level of KCNN4 in pancreatic ductal adenocarcinoma was abnormally elevated, and the overexpression of KCNN4 was induced by transcription factor AP-1.

[Nature Reviews Endocrinology] Scientists discuss the possible mechanisms responsible for endoplasmic reticulum (ER) proteostasis imbalance with a focus on type II diabetes mellitus, in which both genetics and environment are considered important in promoting ER stress in β-cells.

[Science Advances] Researchers demonstrated a multilayer hydrogel nanofilm caging strategy capable of protecting cells from high shear stress and reducing immune response by interfering cell-cell interaction.

[Cell Death & Disease] Researchers found that a novel circular RNA circSLIT2 was significantly upregulated in pancreatic ductal adenocarcinoma tissues and cells.

[JCI Insight] Investigators showed that macrophages contributed significantly to the loss of β-cells and the subsequent development of hyperglycemia. Depletion or inhibition of 12-LOX in this model resulted in reduced macrophage infiltration into islets and the preservation of β-cell mass.

[Cell Death & Differentiation] Scientists demonstrated that SIRT1/CUL4B promoted CSC-like properties, including increased stemness marker expression and sphere formation.