pancreatic cells

[Diabetes] Researchers constructeded a multidimensional map of β cell transcriptional trajectories during the normal course of β cell postnatal development and during their dedifferentiation in models of both type I diabetes and type II diabetes.

[Cell Death & Disease] The pancreas was analyzed by histology, immunochemistry staining, and TUNEL assays, and the expression of certain proteins and RNAs, cytokine levels, trypsin activity, and reactive oxygen species (ROS) levels were determined.

[Chemico-Biological interactions] The effects of prodrug 1 were studied in lipopolysaccharide-induced in vitro and in vivo apoptosis and pancreatitis models by determining the cellular apoptotic levels with human umbilical vein endothelial cells and pancreatic caspase-3/-7 activity in mice.

[Nature Communications] LINC00842 expression was upregulated in pancreatic ductal adenocarcinoma and induced by high concentration of glucose via transcription factor YY1.

[Cancer Research] Reserachers showed inhibition of glucose metabolism with low dose 2-deoxyglucose in combination with a MEK inhibitor induced apoptosis in KrasG12D-driven pancreatic ductal adenocarcinoma cells in vitro.

[Advanced Science] The design considerations and functional requirements of macroencapsulation systems are reviewed, specifically for stem-cell derived islets, highlighting distinct design parameters.