pancreatic ductal adenocarcinoma

[Cancer and Metastasis Reviews] Recent studies of the human microbiome have offered new insights into how the microbiome can impact cancer development and treatment. Specifically, in PDAC, the microbiota has been shown to modulate PDAC risk, contribute to tumorigenesis, impact the tumor microenvironment, and alter treatment response.

[Journal of Experimental & Clinical Cancer Research] The mechanism of circRHOBTB3 regulatory role was validated by pull-down assays, RIP, luciferase reporter assays.

[Communications Biology] In vitro results showed that low-density lipoprotein receptor (LDLR)-targeting conjugate entered into PDAC cells through LDLR mediated-endocytosis before trafficking to the late endosome/lysosome pathway, emulating the natural ligand low-density lipoprotein.

[Cell] Researchers found that Pin1 was overexpressed both in cancer cells and cancer-associated fibroblasts and correlated with poor survival in pancreatic ductal adenocarcinoma patients.

[Experimental Cell Research] Researchers explored the interplay between epidermal growth factor receptor kinase substrate 8 and aldehyde dehydrogenase 7 family member A1 (ALDH7A1) in pancreatic ductal adenocarcinoma (PADC) cells. PADC cell lines MIA PaCa-2 and AsPANC-1 were used for in vitro and in vivo studies.

[Cancer Immunology Immunotherapy] Researchers studied the interaction between pancreatic ductal adenocarcinoma (PDAC) cells and pancreatic stellate cells (PSCs) in vitro and verified their finding with the survival data of patients with PDAC from the website of The Human Protein Atlas.