pancreatic ductal adenocarcinoma

[Journal of Biological Chemistry] Researchers examined differences in N-glycans, O-glycans, and glycosphingolipid glycans in PaTu-8955S (PaTu-S) cells upon TGF-β stimulation.

[Immunity] Researchers examined the impact of aryl hydrocarbon receptor in tumor-associated macrophage function in pancreatic ductal adenocarcinoma.

[Nature Communications] Scientists demonstrated that yeast-derived particulate β-glucan, an inducer of trained immunity, trafficed to the pancreas, which caused a CCR2-dependent influx of monocytes/macrophages to the pancreas that display features of trained immunity.

[Scientific Reports] K3-SPG, a second-generation nanoparticulate Toll-like receptor 9 (TLR9) ligand consisting of K-type CpG oligodeoxynucleotide (ODN) wrapped with schizophyllan, integrated the best of conventional CpG ODNs, making it an ideal cancer immunotherapy adjuvant.

[Journal of Magnetic Resonance Imaging] Scientists investigate and summarize the advantages, limitations, and future development of magnetic resonance imaging in the evaluation of neoadjuvant treatment of pancreatic ductal adenocarcinoma.

[Cancer Cell] The authors showed that oncogenic KrasG12D increased IL-33 expression in PDAC cells, which recruited and activated TH2 and innate lymphoid cells 2 cells.