Tag results:
pancreatitis
Immune Regulation News
PD-1 Cooperates with AIRE-Mediated Tolerance to Prevent Lethal Autoimmune Disease
[Proceedings of the National Academy of Sciences of the United States of America] Using a range of mouse genetic models, researchers uncovered a critical tolerogenic axis between the autoimmune regulator, AIRE, and the immune checkpoint molecule, PD-1.
Immune Regulation News
PD-1 Cooperates with AIRE-Mediated Tolerance to Prevent Lethal Autoimmune Disease
[Proceedings of the National Academy of Sciences of the United States of America] Using a range of mouse genetic models, researchers uncovered a critical tolerogenic axis between the autoimmune regulator, AIRE, and the immune checkpoint molecule, PD-1.
Pancreatic Cell News
Downregulation of lncRNA NEAT1 Relieves Caerulein-Induced Cell Apoptosis and Inflammatory Injury in AR42J Cells through Sponging MiR-365a-3p in Acute Pancreatitis
[Biochemical Genetics] Investigators explored the role of long-noncoding RNA nuclear paraspeckle assembly transcript 1 (NEAT1) in acute pancreatitis that was induced by caerulein in rat pancreatic acinar cells AR42J.
Human Immunology News
PD-1 Blockade with Pembrolizumab in Classic or Endemic Kaposi’s Sarcoma: A Multicentre, Single-Arm, Phase II Study
[Lancet Oncology] Investigators evaluated the activity of pembrolizumab in classic and endemic Kaposi sarcoma with cutaneous extension requiring systemic treatment.
Pancreatic Cell News
Excess Fatty Acids Induce Pancreatic Acinar Cell Pyroptosis through Macrophage M1 Polarization
[BMC Gastroenterology] Scientists found that palmitic acid stimulation led to M1 polarization of macrophage, which secreted cathepsin S via exosomes to pancreatic acinar cells and led to activation of the caspase1-mediated classical pyrolysis pathway.
Pancreatic Cell News
Excess Fatty Acids Induce Pancreatic Acinar Cell Pyroptosis through Macrophage M1 Polarization
[BMC Gastroenterology] Scientists found that palmitic acid stimulation led to M1 polarization of macrophage, which secreted cathepsin S via exosomes to pancreatic acinar cells and led to activation of the caspase1-mediated classical pyrolysis pathway.