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pancreatitis

PD-1 Cooperates with AIRE-Mediated Tolerance to Prevent Lethal Autoimmune Disease

[Proceedings of the National Academy of Sciences of the United States of America] Using a range of mouse genetic models, researchers uncovered a critical tolerogenic axis between the autoimmune regulator, AIRE, and the immune checkpoint molecule, PD-1.

PD-1 Cooperates with AIRE-Mediated Tolerance to Prevent Lethal Autoimmune Disease

[Proceedings of the National Academy of Sciences of the United States of America] Using a range of mouse genetic models, researchers uncovered a critical tolerogenic axis between the autoimmune regulator, AIRE, and the immune checkpoint molecule, PD-1.

Downregulation of lncRNA NEAT1 Relieves Caerulein-Induced Cell Apoptosis and Inflammatory Injury in AR42J Cells through Sponging MiR-365a-3p in Acute Pancreatitis

[Biochemical Genetics] Investigators explored the role of long-noncoding RNA nuclear paraspeckle assembly transcript 1 (NEAT1) in acute pancreatitis that was induced by caerulein in rat pancreatic acinar cells AR42J.

PD-1 Blockade with Pembrolizumab in Classic or Endemic Kaposi’s Sarcoma: A Multicentre, Single-Arm, Phase II Study

[Lancet Oncology] Investigators evaluated the activity of pembrolizumab in classic and endemic Kaposi sarcoma with cutaneous extension requiring systemic treatment.

Excess Fatty Acids Induce Pancreatic Acinar Cell Pyroptosis through Macrophage M1 Polarization

[BMC Gastroenterology] Scientists found that palmitic acid stimulation led to M1 polarization of macrophage, which secreted cathepsin S via exosomes to pancreatic acinar cells and led to activation of the caspase1-mediated classical pyrolysis pathway.

Excess Fatty Acids Induce Pancreatic Acinar Cell Pyroptosis through Macrophage M1 Polarization

[BMC Gastroenterology] Scientists found that palmitic acid stimulation led to M1 polarization of macrophage, which secreted cathepsin S via exosomes to pancreatic acinar cells and led to activation of the caspase1-mediated classical pyrolysis pathway.

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