Dipeptidyl Peptidase 4 Inhibitors in the Treatment of Type 2 Diabetes Mellitus

The authors discuss the use of dipeptidyl peptidase 4 inhibitors (DPP4i) in the treatment of type 2 diabetes mellitus, highlighting their benefits and risks. They focus primarily on the five DPP4i with the widest geographical distribution.
[Nature Reviews Endocrinology]
Deacon, C. F. (2020). Dipeptidyl peptidase 4 inhibitors in the treatment of type 2 diabetes mellitus. Nature Reviews Endocrinology, 1–12. https://doi.org/10.1038/s41574-020-0399-8 Cite
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The Gustatory Sensory G-Protein GNAT3 Suppresses Pancreatic Cancer Progression in Mice

Compromised gustatory sensing, achieved by Gnat3 ablation, enhanced the CXCL1/2 – CXCR2 axis to alter the myeloid-derived suppressor cell population and promoted the progression of metastatic pancreatic ductal adenocarcinoma.
[Cellular and Molecular Gastroenterology and Hepatology]
Hoffman, M. T., Kemp, S. B., Salas-Escabillas, D. J., Zhang, Y., Steele, N. G., The, S., Long, D., Benitz, S., Yan, W., Margolskee, R. F., Bednar, F., Pasca di Magliano, M., Wen, H.-J., & Crawford, H. C. (2020). The Gustatory Sensory G-Protein GNAT3 Suppresses Pancreatic Cancer Progression in Mice. Cellular and Molecular Gastroenterology and Hepatology. https://doi.org/10.1016/j.jcmgh.2020.08.011 Cite
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Extracellular Cold-Inducible RNA-Binding Protein Regulates Neutrophil Extracellular Trap Formation and Tissue Damage in Acute Pancreatitis

Scientists studied the role of extracellular cold-inducible RNA-binding protein, a novel damage-associated-molecular-pattern molecule, in severe acute pancreatitis.
[Laboratory Investigation]
Linders, J., Madhi, R., Rahman, M., Mörgelin, M., Regner, S., Brenner, M., Wang, P., & Thorlacius, H. (2020). Extracellular cold-inducible RNA-binding protein regulates neutrophil extracellular trap formation and tissue damage in acute pancreatitis. Laboratory Investigation, 1–13. https://doi.org/10.1038/s41374-020-0469-5 Cite
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κB-Ras and Ral GTPases Regulate Acinar to Ductal Metaplasia during Pancreatic Adenocarcinoma Development and Pancreatitis

Scientists showed that low expression of κB-Ras GTPases was frequently detected in pancreatic ductal adenocarcinoma and correlated with higher histologic grade.
[Nature Communications]
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ANGPTL 4 Exacerbates Pancreatitis by Augmenting Acinar Cell Injury through Upregulation of C5a

The authors’ microarray analysis of pancreatic tissues from mild and severe acute pancreatitis mice models identified angiopoietin‐like 4 (ANGPTL 4) as one of the most significantly upregulated genes.
[EMBO Molecular Medicine]
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Identification of a Novel IL-5 Signaling Pathway in Chronic Pancreatitis and Crosstalk with Pancreatic Tumor Cells

The expression of IL-5R and the effects of IL-5 were analyzed in human and murine tumor cells.
[Cell Communication and Signaling]
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BAP1 Is a Haploinsufficient Tumor Suppressor Linking Chronic Pancreatitis to Pancreatic Cancer in Mice

Researchers found that heterozygous loss of histone H2A lysine 119 deubiquitinase BRCA1 Associated Protein-1 associates with a history of chronic pancreatitis and occurs in 25% of pancreatic ductal adenocarcinomas and 40% of acinar cell carcinomas.
[Nature Communications]
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