pancreatitis

[Cell Death & Disease] A novel lncRNA named long non-coding RNA (lncRNA) was found highly expressed in mouse and human chronic pancreatitis tissues.

[Communications Biology] In vitro results showed that low-density lipoprotein receptor (LDLR)-targeting conjugate entered into PDAC cells through LDLR mediated-endocytosis before trafficking to the late endosome/lysosome pathway, emulating the natural ligand low-density lipoprotein.

[Acta Pharmacologica Sinica] Scientists investigated the effect and underlying mechanism of (R)-4,6-dimethoxy-3-(4-methoxy phenyl)-2,3-dihydro-1H-indanone on acute pancreatitis.

[Gastroenterology] Pancreas-specific Agr2 ablation was performed to access its role in pancreatic carcinogenesis. Hydrophobic hexapeptides loaded in liposomes were developed to disrupt Agr2-RNAPII complex.

[Journal of Gastroenterology] Researchers discussed the intracellular signal events contributing to pancreatic myofibroblasts activation, and crosstalk with different components of tumor microenvironment.

[Nature Communications] In isolated pancreatic acinar cells, insulin induced Akt-mediated phosphorylation of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (PFKFB2) which upregulated glycolysis thereby preventing POA-induced ATP depletion.