Researchers provide direct genetic evidence that Sox2 is necessary for androgen ablation-induced neuroendocrine differentiation of Pten null prostate adenocarcinoma. They corroborate that the lineage status of the prostate cancer cells is a determinant for its propensity to exhibit lineage plasticity, and support that the intrinsic features of cell-of-origin for prostate cancers can dictate their clinical behaviors.
To discover modulators of androgen receptor (AR)-variant activity, investigtors used a lysate-based small-molecule microarray assay and identified KI-ARv-03 as an AR-variant complex binder that reduced AR-driven transcription and proliferation in prostate cancer cells.
[Cell Chemical Biology]
6630899 WYFUJNXL items 1 apa default asc 1
Richters, A., Doyle, S. K., Freeman, D. B., Lee, C., Leifer, B. S., Jagannathan, S., Kabinger, F., Koren, J. V., Struntz, N. B., Urgiles, J., Stagg, R. A., Curtin, B. H., Chatterjee, D., Mathea, S., Mikochik, P. J., Hopkins, T. D., Gao, H., Branch, J., Xin, H., … Koehler, A. N. (2020). Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors. Cell Chemical Biology, 0(0). https://doi.org/10.1016/j.chembiol.2020.10.001 Cite
Scientists demonstrated for the first time a miR-106b dependent downregulation of RBMS1 in prostate carcinoma. Additionally, they showed new tumour suppressive properties of RBMS1 whose observed loss may further elucidate the development of prostate carcinoma.
6630899 EYR9Y7L9 items 1 apa default asc 1
Calcitonin gene-related peptide treatment activated extracellular signal-regulated kinases/Signal transducer and activator of transcription 3 signaling in prostate cancer cells.
PC-3 cells were cultured in adherence and/or spheroid culture system. The cells were treated with different concentrations of Rosuvastatin. After 96 hours, the cell proliferation, viability, type and number of spheroids, the expression of E-Cadherin, Vimentin and Zeb-1 were analyzed.
[Molecular Biology Reports]
The authors present evidence that in the prostate cancer cell line DU145, the tubules arise in actively growing cells from vesicles in the medial and trans elements of a partially fragmented Golgi complex, while in not actively growing cells the tubules become completely independent from the Golgi complex.
[Experimental Cell Research]
6630899 3U8VXEG3 items 1 apa default asc 1
Nolfi, D., Capone, A., Rosati, F., & Della Giovampaola, C. (2020). The alpha-1,2 fucosylated tubule system of DU145 prostate cancer cells is derived from a partially fragmented Golgi complex and its formation is actin-dependent. Experimental Cell Research, 396(2), 112324. https://doi.org/10.1016/j.yexcr.2020.112324 Cite
The authors suggest that ROS-mediated genotoxic stress is involved in NaAsO2-induced cell cycle arrest, stemness enhancement and chemoresistance of prostate cancer cells in a p53-independent manner.
[Ecotoxicology and Environmental Safety]
6630899 2P9MBRAM items 1 apa default asc 1
Zhang, Z.-H., Hong, Q., Zhang, Z.-C., Xing, W.-Y., Xu, S., Tian, Q.-X., Ye, Q.-L., Wang, H., Yu, D.-X., Xie, D.-D., & Xu, D.-X. (2021). ROS-mediated genotoxic stress is involved in NaAsO2-induced cell cycle arrest, stemness enhancement and chemoresistance of prostate cancer cells in a p53-independent manner. Ecotoxicology and Environmental Safety, 208, 111436. https://doi.org/10.1016/j.ecoenv.2020.111436 Cite
Transplantation of CD63-Antares2-expressing prostate cancer cells into mice allowed determining the amount of cancer-derived exosomes released from primary tumors into the bloodstream and visualizing the long-term homing behavior of exosomes to their target organs or tissues.
Researchers investigated whether the down-regulation of Scm-like with four mbt domains 2 (SFMBT2) regulated the infiltration of preadipocytes and tumor-associated macrophages in prostate cancer.
Investigators attempted to identify a LNCaP95 clone that would be useful for evaluating therapies for their effectiveness against enzalutamide-resistant prostate cancer cells.
The downregulation of PCDH9 in pancreatic cells resulted in an increase in AKT phosphorylation and activity. PCDH9 was posttranscriptionally regulated by P-element-induced wimpy-interacting (piR)-001773 and piR-017184.