The authors reported that mammalian target of rapamycin (mTOR) is a key regulator of hyaluronan-mediated motility receptor (HMMR) expression, for which its kinase activity is required. Pharmacological inhibitors of mTOR markedly suppressed the mRNA level as well as the protein level of HMMR in LNCaP and PC-3 cells.
[Biomolecules & Therapeutics]
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NUC-1031 preferentially targeted leukemic stem cells in primary AML samples and cancer stem cells in the prostate cancer cell line, LNCaP..
[Journal of Medicinal Chemistry]
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Using genome-wide target capture of miRNAs and miRNA-binding sites followed by deep sequencing in prostate cancer cell lines, researchers identified prostate cancer-specific single nucleotide variants in mature miRNAs and their target binding sites.
[Journal of Human Genetics]
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Scientists explored the mechanism of action of Maytenus royleanus (MEM) in prostate cancer (PCa) by employing an in vitro global proteome approach to get useful information of various signaling pathways and effected genes to define the mechanism of MEM action in Pca.
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Treatment of C4-2 cells with the 4F2 cell-surface antigen heavy chain was found to suppress cellular growth, migratory and invasive abilities, with this effect occurring through the cell cycle, with a significant decrease in S phase and a significant increase in G0/G1 phase, suggesting cell cycle arrest.
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Researchers found that depletion of either FKBP51 or FKBP52 reduced androgen receptor(AR) dimer formation, chromatin binding and phosphorylation, suggesting defective AR signaling.
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Anti-cancer activity of catechin nanoemulsions prepared from Oolong tea leaf waste was studied on prostate cancer cells DU-145 and DU-145-induced tumors in mice.
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Investigators observed and investigated the mechanism of induction of SLCO1B3 by abiraterone. Prostate cancer cells were treated with anti-androgens and assessed for SLCO1B3 expression by qPCR analysis.
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The role of the sodium bicarbonate transporters (NBCs) in prostate cancer cell proliferation and viability was examined. PCR revealed heterogeneous expression of five NBC isoforms in human prostate cancer cell lines LNCaP, PC3, 22RV1, C4-2, DU145, and the prostate cell line RWPE-1.
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The authors investigated the potential interactions of (-)-epicatechin and (+)-catechin with the membrane androgen receptor, ZIP9 (SLC39A9), which mediates androgen induction of apoptosis in human breast and prostate cancer cells.
[Journal of Steroid Biochemistry and Molecular Biology]
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The efficiency of water-soluble fullerene nanomaterials as siRNA vehicles was tested in vitro using the prostate cancer cell line DU145 expressing the GFP protein.
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