Tau Oligomers Accumulation Sensitizes Prostate Cancer Cells to Docetaxel Treatment

The authors investigated the potential association between autophagy and tau oligomers accumulation and its role in the response of prostate cancer cells to docetaxel.
[Journal of Cancer Research and Clinical Oncology]
Martellucci, S., Clementi, L., Sabetta, S., Muzi, P., Mattei, V., Bologna, M., & Angelucci, A. (2021). Tau oligomers accumulation sensitizes prostate cancer cells to docetaxel treatment. Journal of Cancer Research and Clinical Oncology. https://doi.org/10.1007/s00432-021-03598-3 Cite
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Inhibition of STAT3 Prevents Bone Metastatic Progression of Prostate Cancer In Vivo

Effects of signal transducer and activator of transcription 3 (STAT3) inhibitors, Stattic and Napabucasin, on metastatic potential in prostate cancer cells were studied in vitro by assessment of migration capacity, self‐renewal potential, and tumorsphere formation.
[Prostate]
Thulin, M. H., Määttä, J., Linder, A., Sterbova, S., Ohlsson, C., Damber, J.-E., Widmark, A., & Persson, E. (n.d.). Inhibition of STAT3 prevents bone metastatic progression of prostate cancer in vivo. The Prostate, n/a(n/a). https://doi.org/https://doi.org/10.1002/pros.24125 Cite
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Pharmacological Effects of Guava (Psidium guajava L.) Seed Polysaccharides: GSF3 Inhibits PC-3 Prostate Cancer Cell Growth through Immunotherapy In Vitro

Guava seed polysaccharides (GSPS), GSF1, GSF2, and GSF3 were isolated using Sepharose 6B gel filtration chromatography to assay their inhibitory effects on prostate PC-3 cell growth with direct action or indirect immunotherapy.
[International Journal of Molecular Sciences]
Lin, H.-C., & Lin, J.-Y. (2021). Pharmacological Effects of Guava (Psidium guajava L.) Seed Polysaccharides: GSF3 Inhibits PC-3 Prostate Cancer Cell Growth through Immunotherapy In Vitro. International Journal of Molecular Sciences, 22(7), 3631. https://doi.org/10.3390/ijms22073631 Cite
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Loss of Ephrin B2 Receptor (EPHB2) Sets Lipid Rheostat by Regulating Proteins DGAT1 and ATGL Inducing Lipid Droplet Storage in Prostate Cancer Cells

Knockdown strategies for EPHB2 were performed in prostate cancer cells to analyze the impact on the net lipid balance, proliferation, triacylglycerol-regulating proteins, effect on lipid droplet (LD) biogenesis, and intracellular localization of LDs.
[Laboratory Investigation]
Morales, A., Greenberg, M., Nardi, F., Gil, V., Hayward, S. W., Crawford, S. E., & Franco, O. E. (2021). Loss of ephrin B2 receptor (EPHB2) sets lipid rheostat by regulating proteins DGAT1 and ATGL inducing lipid droplet storage in prostate cancer cells. Laboratory Investigation, 1–14. https://doi.org/10.1038/s41374-021-00583-9 Cite
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Stomatin-Mediated Inhibition of the Akt Signaling Axis Suppresses Tumor Growth

Investigators found that stomatin expression was markedly upregulated by the interaction between prostate cancer cells and stromal cells.
[Cancer Research]
Rahman, N. I. A., Sato, A., Tsevelnorov, K., Shimizu, A., Komeno, M., Amin, M. K. B. A., Molla, M. R., Soh, J. E. C., Nguyen, L. K. C., Wada, A., Kawauchi, A., & Ogita, H. (2021). Stomatin-mediated inhibition of the Akt signaling axis suppresses tumor growth. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-2331 Cite
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SUMOylation Controls the Binding of Hexokinase 2 to Mitochondria and Protects against Prostate Cancer Tumorigenesis

Investigators report that SUMOylation regulated the binding of hexokinase 2 to mitochondria. They found that hexokinase 2 could be SUMOylated at K315 and K492.
[Nature Communications]
Shangguan, X., He, J., Ma, Z., Zhang, W., Ji, Y., Shen, K., Yue, Z., Li, W., Xin, Z., Zheng, Q., Cao, Y., Pan, J., Dong, B., Cheng, J., Wang, Q., & Xue, W. (2021). SUMOylation controls the binding of hexokinase 2 to mitochondria and protects against prostate cancer tumorigenesis. Nature Communications, 12(1), 1812. https://doi.org/10.1038/s41467-021-22163-7 Cite
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Host Versus Cell-Dependent Effects of β-Arrestin-1 Expression in Prostate Tumorigenesis

The authors investigated the effect of β-arrestin 1 overexpression in prostate cancer development and progression using the mouse and human prostate cancer cell xenografts, and autochthonous transgenic adenocarcinoma mouse prostate models deficient in β-arrestins.
[Carcinogenesis]
Adekoya, T. O., Smith, N., Thomas, A. J., Lane, T. S., Burnette, N., Rivers, E. J., Li, Y., Chen, X. L., & Richardson, R. M. (2021). Host versus cell-dependent effects of β-Arrestin-1 expression in prostate tumorigenesis. Carcinogenesis, bgab021. https://doi.org/10.1093/carcin/bgab021 Cite
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Hormone Dependent Prostate Cancers Are Dependent on Rac Signaling for Growth and Survival

The authors investigated the role of HACE1, the E3 ubiquitin ligase for Rac1, in prostate cancer and found that HACE1 was commonly lost resulting in hyperactive Rac signaling leading to enhanced cellular proliferation, motility and viability. They also showed that a Rac inhibitor could attenuate the growth and survival of prostate cancer cells.
[Molecular Cancer Therapeutics]
Goka, E. T., Lopez, D. T. M., & Lippman, M. E. (2021). Hormone dependent prostate cancers are dependent on Rac signaling for growth and survival. Molecular Cancer Therapeutics. https://doi.org/10.1158/1535-7163.MCT-20-0695 Cite
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2D Exfoliated Black Phosphorus Influences Healthy and Cancer Prostate Cell Behaviors

Researchers investigated nanostructured exfoliated black phosphorus in vitro effect on healthy and cancer prostate cell behavior.
[Scientific Reports]
Fasolino, I., Soriente, A., Caporali, M., Serrano-Ruiz, M., Peruzzini, M., Ambrosio, L., & Raucci, M. G. (2021). 2D exfoliated black phosphorus influences healthy and cancer prostate cell behaviors. Scientific Reports, 11(1), 5856. https://doi.org/10.1038/s41598-021-85310-6 Cite
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Development of EphA2 siRNA-Loaded Lipid Nanoparticles and Combination with a Small-Molecule Histone Demethylase Inhibitor in Prostate Cancer Cells and Tumor Spheroids

Using DDAB cationic lipid instead of DOTMA reduced nanoparticle size and enhanced both cellular uptake and gene silencing in prostate cancer cells.
[Journal of Nanobiotechnology]
Oner, E., Kotmakci, M., Baird, A.-M., Gray, S. G., Debelec Butuner, B., Bozkurt, E., Kantarci, A. G., & Finn, S. P. (2021). Development of EphA2 siRNA-loaded lipid nanoparticles and combination with a small‐molecule histone demethylase inhibitor in prostate cancer cells and tumor spheroids. Journal of Nanobiotechnology, 19(1), 71. https://doi.org/10.1186/s12951-021-00781-z Cite
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Overcoming TRAIL-Resistance by Sensitizing Prostate Cancer 3D Spheroids with Taxanes

DU145 and PC3 cells were cultured as 2D monolayers and 3D spheroids to compare sensitization of TRAIL-resistance cancer cells to TRAIL mediated apoptosis via chemotherapy based on dimensionality.
[PLoS One]
Grayson, K. A., Jyotsana, N., Ortiz-Otero, N., & King, M. R. (2021). Overcoming TRAIL-resistance by sensitizing prostate cancer 3D spheroids with taxanes. PLOS ONE, 16(3), e0246733. https://doi.org/10.1371/journal.pone.0246733 Cite
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