prostate cancer cells

[iScience] Scientists reported that neutrophil elastase triggered dose-dependent ERK signaling and cell migration in a panel of prostate cell lines representing the spectrum of prostate cell malignancy.

[Molecular and Cellular Endocrinology] The authors reported that testosterone, independently of the presence of the classical androgen receptor, rapidly increased intracellular calcium from calcium stores, through the oxoeicosanoid receptor 1 (OXER1) and a signaling cascade that triggered calcium release from the endoplasmic reticulum.

[BMC Cancer] Investigators conducted microarray gene expression analysis and compared FX-9 exposed and unexposed prostate cancer cells, followed by pathway analysis and gene annotation to functional processes.

[Molecular Cancer Research] The authors showed that GLI3, a key SHH pathway effector, was transcriptionally upregulated during androgen deprivation and posttranslationally stabilized in prostate cancer cells by mutation of speckle-type POZ protein.

[Chemistry & Biodiversity] Investigators synthesized 3'- O -substituted quercetin as isorhamnetin analogues and evaluated the growth inhibitory activity of these derivatives on breast, colon and prostate cancer cell lines.

[Prostate Cancer and Prostatic Diseases] Researchers used screening tests for candidate drugs targeting cabazitaxel (CBZ)-resistant-related gene expression and identified pimozide as a potential candidate for overcoming CBZ resistance in castration-resistant prostate cancer.