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prostate cancer cells

Silencing of TP73-AS1 Impairs Prostate Cancer Cell Proliferation and Induces Apoptosis via Regulation of TP73

[Molecular Biology Reports] Investigators provided novel evidence that suggests a chief regulatory role for the TP73-TP73-AS1 axis in prostate cancer development and progression, suggesting that the TP73/TP73-AS1 axis can be a promising diagnostic and therapeutic target for prostate cancer.

Autophagy Deficiency Promotes Lung Metastasis of Prostate Cancer via Stabilization of TWIST1

[Clinical and Translational Oncology] The authors revealed ATG5-mediated autophagy was a key mechanism that controled the metastasis of prostate cancer by regulating p62 abundance and TWIST1 stabilization.

Fibroblast Activation Protein-Alpha Knockdown Suppresses Prostate Cancer Cell Invasion and Proliferation

[Histology and Histopathology] Real-time quantitative PCR was used to detect the relative expression of fibroblast activation protein alpha mRNA in prostate cancer cell lines and human normal prostate epithelial cell line RWPE-1.

SU086, an Inhibitor of HSP90, Impairs Glycolysis and Represents a Treatment Strategy for Advanced Prostate Cancer

[Cell Reports Medicine] The authors demonstrated that SU086 inhibited the growth of prostate cancer cells in vitro, cell-line and patient-derived xenografts in vivo, and ex vivo prostate cancer patient specimens.

Selective Vulnerabilities in the Proteostasis Network of Castration-Resistant Prostate Cancer

[Cell Chemical Biology] Investigators performed functional and synthetic lethal screens in four prostate cancer cell lines which confirmed key roles for HSP70, HSP90, and their co-chaperones, and suggested that the mitochondrial chaperone, HSP60/HSPD1, was selectively required in CRPC cell lines.

An Oral First-in-Class Small Molecule RSK Inhibitor Suppresses AR Variants and Tumor Growth in Prostate Cancer

[Cancer Science] Scientists investigated the effect of PMD-026 on YB-1/AR signaling and its antitumor effect in prostate cancer in vitro and in vivo and demonstrated an excellent antitumor effect of the novel ribosomal S6 kinase inhibitor PMD-026 and the combination effect with the antiandrogen enzalutamide in CRPC.

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