prostate cancer

[Daru-Journal of Pharmaceutical Sciences] Scientists analyzed the phytochemistry and screen the cytotoxic activity of new bioactive compounds against a panel of cancer cells, in addition to proapototic properties against prostate cancer cells.

[Cell Death & Differentiation] Genetic ablation of OTUD6A efficiently repressed prostatic tumorigenesis of both human prostate cancer (PrCa) cells and the Hi-Myc transgenic PrCa mice, via reversing the metabolic remodeling caused by c-Myc overexpression in PrCa.

[Aging] Investigators administrated Qi Ling (QL) to rats and collected the serum from QL-treated rats and established the co-culture system of tumor-associated macrophages/paclitaxel resistant prostate cancer cells.

[International Journal of Oncology] Liquid chromatography‑tandem mass spectrometry and gas chromatography‑mass spectrometry assays were performed, and the results revealed markedly reduced levels of glutamine and metabolic flux in the blood samples of patients with prostate cancer (PCa) and in PCa cells.

[Bioengineered] The expression of HSP90 and IL-6 was upregulated and that of androgen receptor was downregulated by knocking down lung cancer metastasis-related protein 1 or GRα in CRPC cells.

[Oncogenesis] Researchers integrated human studies, genetic mouse modeling, and cellular systems to characterize the regulation and function of glycine N-Methyltransferase in prostate cancer.