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prostate cancer

MYB Interacts with Androgen Receptor, Sustains Its Ligand-Independent Activation and Promotes Castration Resistance in Prostate Cancer

[British Journal of Cancer] Scientists investigated MYB-androgen receptor crosstalk and its functional significance. MYB-overexpressing prostate cancer cells exhibited greater tumorigenicity when implanted orthotopically and quickly regained growth following castration leading to shorter mice survival.

Imatinib Mesylate Inhibits Androgen-Independent PC-3 Cell Viability, Proliferation, Migration, and Tumor Growth by Targeting Platelet-Derived Growth Factor Receptor-α

[Life Sciences] The authors examined the role of platelet-derived growth factor receptors (PDGFRs) in androgen-independent PC-3 cells and found that PDGFRα was upregulated in androgen-independent PC-3 cells compared with normal prostate epithelial cells.

Extracellular Vesicles as a Source of Prostate Cancer Biomarkers in Liquid Biopsies: A Decade of Research

[British Journal of Cancer] Prostate cancer is a global cancer burden and considerable effort has been made through the years to identify biomarkers for the disease. Investigators present the knowledge acquired during the last decade that constitutes a solid basis for the future development of liquid biopsy tests for prostate cancer.

Non-Invasive Urine Metabolomics of Prostate Cancer and Its Therapeutic Approaches: A Current Scenario and Future Perspective

[Expert Review of Proteomics] The authors provide a concise overview of the prostate cancer metabolomics-based potential discriminating molecules in urine samples using nuclear magnetic resonance spectroscopy and mass spectrometry.

lncRNA Prostate Cancer-Associated Transcript 18 Upregulates Activating Transcription Factor 7 to Prevent Metastasis of Triple-Negative Breast Cancer via Sponging miR-103a-3p

[Bioengineered] Prostate cancer-associated transcript 18 (PCAT18) was expressed at low levels in TNBC, and PCAT18 could sponge miR-103a-3p and promote activating transcription factor 7 expression, resulting in prevention of TNBC metastasis.

TCF7L1 Regulates Cytokine Response and Neuroendocrine Differentiation of Prostate Cancer

[Oncogenesis] Researchers identified androgen-deprivation therapy-mediated upregulation of transcription factor 7 like 1 (TCF7L1), which increased the cytokine response and enhanced neuroendocrine differentiation of prostate cancer through interleukin-8/C-X-C motif chemokine receptor type 2 signaling activation.

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