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prostate cancer

The Isoflavanoid (+)-PTC Regulates Cell-Cycle Progression and Mitotic Spindle Assembly in a Prostate Cancer Cell Line

[Chemistry & Biodiversity] Scientists evaluated, using flow cytometry, confocal microscopy and image analysis, the anti-proliferative effects of (+)-2,3,9-trimethoxypterocarpan on relevant human prostate cancer cells as well as its capacity to control mitosis within them.

GATA Binding Protein 5-Mediated Transcriptional Activation of Transmembrane Protein 100 Suppresses Cell Proliferation, Migration and Epithelial-to-Mesenchymal Transition in Prostate Cancer DU145 Cells

[Bioengineered] The authors uncovered the role of GATA binding protein 5-mediated activation of transmembrane protein 100 in the proliferation, migration and epithelial-to-mesenchymal transition of prostate cancer cells.

Cistrome and Transcriptome Analysis Identifies Unique Androgen Receptor (AR) and AR-V7 Splice Variant Chromatin Binding and Transcriptional Activities

[Scientific Reports] LNCaP and VCaP cell lines in which androgen receptor (AR)-V7 expression can be induced to match the level of AR, were used to compare the activities of AR and AR-V7.

Mismatch Repair Deficiency and Clinical Implications in Prostate Cancer

[Prostate] The authors focus on mismatch repair deficiency in prostate cancer, highlighting the clinical implications, role of immunotherapy, and areas of future research.

Inherited Risk Assessment and Its Clinical Utility for Predicting Prostate Cancer from Diagnostic Prostate Biopsies

[Prostate Cancer and Prostatic Diseases] An integrative review was performed to critically synthesize findings on prostate cancer germline studies from published papers since 2016.

GIPC2 Interacts with Fzd7 to Promote Prostate Cancer Metastasis by Activating WNT Signaling

[Oncogene] Functional studies demonstrated that high GIPC2 expression due to CpG-island demethylation promoted increased metastatic capabilities of prostate cancer cells.

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