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prostate cancer

Metformin Exerts Anti-AR-Negative Prostate Cancer Activity via AMPK/Autophagy Signaling Pathway

[Cancer Cell International] Scientists explored the mechanism involved in metformin-mediated inhibition of AR-negative prostate cancer.

Carrick Therapeutics Receives FDA Fast Track Designations for Two Samuraciclib Combinations for the Treatment of HR+, HER2– Advanced Breast Cancer and Locally Advanced or...

[Carrick Therapeutics] Carrick Therapeutics announced that the US FDA has granted Fast Track designations to samuraciclib in combination with fulvestrant for CDK4/6i resistant HR+, HER2- advanced breast cancer and samuraciclib in combination with chemotherapy for the treatment of locally advanced or metastatic TNBC.

A Feedback Loop between the Androgen Receptor and 6-Phosphogluoconate Dehydrogenase (6PGD) Drives Prostate Cancer Growth

[eLife] The authors identified 6-phosphogluoconate dehydrogenase as an androgen-regulated gene that was upregulated in prostate cancer.

KAT2A-Mediated AR Translocation into Nucleus Promotes Abiraterone-Resistance in Castration-Resistant Prostate Cancer

[Cell Death & Disease] The authors found that KAT2A expression was increased in abiraterone-resistant prostate cancer C4-2 cells

Hemin Activation Abrogates Mycoplasma hyorhinis Replication in Chronically Infected Prostate Cancer Cells via Heme Oxygenase-1 Induction

[FEBS Openbio] Researchers described the striking >90% inhibitory effect of hemin, a natural inducer of the cytoprotective enzyme heme oxygenase-1, on M. hyorhinis replication in chronically infected LNCaP prostate cancer cells.

Aromatic Monophenols from Cinnamon Bark Act as Proteasome Inhibitors by Upregulating ER Stress, Suppressing FoxM1 Expression, and Inducing Apoptosis in Prostate Cancer Cells

[Phytotherapy Research] Scientists investigated the anticancer potential of abundant monophenols from cinnamon, namely, cinnamaldehyde, cinnamic acid, and eugenol, by hypothesizing that they possess proteasome inhibitory activities capable of suppressing cancer cell proliferation and inducing apoptosis.

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