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prostate cells

TCF7L1 Regulates Cytokine Response and Neuroendocrine Differentiation of Prostate Cancer

[Oncogenesis] Researchers identified androgen-deprivation therapy-mediated upregulation of transcription factor 7 like 1 (TCF7L1), which increased the cytokine response and enhanced neuroendocrine differentiation of prostate cancer through interleukin-8/C-X-C motif chemokine receptor type 2 signaling activation.

Prognostic and Therapeutic Significance of COP9 Signalosome Subunit CSN5 in Prostate Cancer

[Oncogene] Deregulation of CSN5, a putative androgen receptor (AR), could affect diverse cellular functions that contribute to tumor development. Inhibition of CSN5 repressed metabolic pathways, including oxidative phosphorylation and glycolysis in AR-negative prostate cancer cells.

PCK1 Regulates Neuroendocrine Differentiation in a Positive Feedback Loop of LIF/ZBTB46 Signaling in Castration-Resistant Prostate Cancer

[British Journal of Cancer] Investigators identified that PCK1 was a pivotal regulator in therapy-induced neuroendocrine differentiation of prostate cancer through a LIF/ZBTB46-driven glucose metabolism pathway.

TMPRSS4 Promotes Cancer Stem–Like Properties in Prostate Cancer Cells through Upregulation of SOX2 by SLUG and TWIST1

[Journal of Experimental & Clinical Cancer Research] The authors investigated whether transmembrane serine protease 4 (TMPRSS4) confered cancer stem–like properties to prostate cancer cells and characterized the underlying mechanisms.

Oxaliplatin Inhibits Angiogenin Proliferative and Cell Migration Effects in Prostate Cancer Cells

[Journal of inorganic Biochemistry] Microscopy cellular studies, carried out on the prostate cancer cell line, showed that oxaliplatin inhibited the angiogenin prompting effect on cell proliferation and migration, which were typical features of angiogenesis process.

Communication between Cells: Exosomes as a Delivery System in Prostate Cancer

[Cell Communication and Signaling] Investigators extrapolate the most relevant papers about the role of exosomes in prostate cancer malignancy and progression. Emerging data concerning the use of these vesicles in diagnostic management and therapeutic guidance of prostate cancer patients are also presented.

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