prostate cells

[Scientific Reports] In vitro analyses confirmed association between overexpression of miR-17-5p and proliferation, migration and invasion in prostate cancer cell lines.

[Scientific Reports] Through a kinome-centered CRISPR-Cas9 screen in CWR-R1 prostate cancer cells, scientists identified activated BRAF signaling as a determinant for enzalutamide resistance.

[Cancer Targeted Technology (Business Wire, Inc.)] Cancer Targeted Technology received a milestone payment from Advanced Accelerator Applications International S.A. triggered by the upcoming clinical trials of investigational 18F-CTT1057, a diagnostic PET imaging agent for prostate cancer.

[Journal of Biomedical Materials Research Part A] The rheological and mechanical properties of the prepared hydrogels were characterized, as well as in vitro release of the paclitaxel and in vitro activity on PC-3 prostate cancer cells.

[Science Advances] Scientists used an all-human microtissue-engineered model of mineralized metastatic tissue combining human osteoprogenitor cells, 3D printing and prostate cancer cells, to assess the effects of the antiandrogens, bicalutamide, and enzalutamide in a microenvironment.

[Science Translational Medicine] Investigators demonstrated that mRNA delivery by polymeric nanoparticles could effectively induce expression of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) in Pten-mutated melanoma cells and Pten-null prostate cancer cells, which in turn induced autophagy and triggered cell death–associated immune activation via release of damage-associated molecular patterns.