protein expression

[npj Breast Cancer] Investigators demonstrated that endoplasmic reticulum stress could decrease androgen receptor mRNA and protein levels via PERK/eIF2α/ATF4 signaling in luminal androgen receptor TNBC and prostate cancer.

[International Journal of Molecular Medicine] The altered expression of microRNAs has been found in asthma. However, the detailed mechanisms responsible for the effects of miR‑375 on Dex‑induced airway epithelial cell dysfunction remain elusive. Researchers elucidated these mechanisms.

[Toxicology and Applied Pharmacology] Scientists performed colony formation assays, soft-agar assays, and tumor growth in nude mice to show that 100 mg/L Nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) facilitated the malignant transformation of human bronchial epithelial Beas-2B cells.

[Bioengineered] Scientists constructed prostate-specific membrane antigen (PSMA)-knockdown LNCaP and 22rv1 cell lines and performed metabonomic and transcriptomic analyses to determine the effects of PSMA on prostate cancer metabolism and transcription.

[Stem Cell Reports] Scientists reported on reprogramming of fibroblasts from two Duchenne muscular dystrophy mouse models into induced myogenic progenitor cells by MyoD overexpression in concert with small molecule treatment.

[International Journal of Oncology] The authors evaluated the effects of tumor‑treating fields with different duty cycles on glioma spheroid cells and normal brain organoids.