protein expression

[Journal of Cellular Biochemistry] Scientists revealed the differences in methionine metabolism of bone marrow (BM)-mesenchymal stem cells (MSCs), umbilical cord blood-MSCs, and cancer stem cells, which reflect different metabolic profiles and developmental stages of stem cells.

[Nature Chemical Biology] Scientists engineered a genetic code expansion-based therapeutic system, termed noncanonical amino acids (ncAAs)-triggered therapeutic switch, to achieve fast therapeutic protein expression in response to cognate ncAAs at the translational level.

[Cell Death & Disease] Investigators showed that the supernatant from ubiquitin-specific protease 12 (USP12)-overexpressing breast cancer cells could promote angiogenesis according to HUVEC migration and tube formation assays.

[Scientific Reports] The authors revealed the important role of insulin gene enhancer-binding protein 1 (ISL1) in androgen receptor (AR)-dependent prostate cancer cell growth; ISL1 knockdown reduced the AR activity and cell growth.

[Nature Communications] The authors introduced a method that simultaneously measured protein expression and thermal stability changes in cells and provided the web-based visualization tool ProteoTracker, and applied their method to study differences between human PSCs and several cell types.

[Scientific Reports] Scientists utilized cromolyn, a mast cell inhibitor with anti-inflammatory capabilities, and its fluorinated analogue F-cromolyn to study fibrosis-related protein regulation and secretion downstream of neuroinflammation and their ability to promote microglial phagocytosis and neurite outgrowth.