Novel Inhibitor of Hematopoietic Cell Kinase as a Potential Therapeutic Agent for Acute Myeloid Leukemia

Scientists investigated in vitro, ex vivo and in vivo effects of a novel chemical compound targeting HCK inhibition, in combination with the most used drugs for the treatment of myelodysplastic syndrome and de novo acute myeloid leukemia, 5-Azacytidine and Cytarabine.
[Cancer Immunology Immunotherapy]
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Thymosin Beta-4 Improves Endothelial Function and Reparative Potency of Diabetic Endothelial Cells Differentiated from Patient Induced Pluripotent Stem Cells

Scientists assessed the role of thymosin β-4 on endothelial function using diabetic human induced pluripotent stem cells derived endothelial cells as disease model of endothelial dysfunction.
[Stem Cell Research & Therapy]
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Eukaryotic Initiation Factor 6 Regulates Mechanical Responses in Endothelial Cells

Eukaryotic initiation factor 6 (eIF6)-depleted endothelial cells, under basal conditions, exhibit unchanged nascent protein synthesis, polysome profiles, and cytoskeleton protein expression. The authors showed that eIF6 was required for the correct spatial mechanoactivation of ERK1/2 via stabilization of an eIF6–RACK1–ERK1/2–FAK mechanocomplex
[Journal of Cell Biology]
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Fewer LAG-3+ T Cells in Relapsing-Remitting Multiple Sclerosis and Type 1 Diabetes

The authors observed significantly fewer LAG-3+ CD4 and CD8 T cells from subjects with relapsing-remitting multiple sclerosis and type 1 diabetes.
[Journal of Immunology]
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Endoplasmic Reticulum Stress Inhibits AR Expression via the PERK/eIF2α/ATF4 Pathway in Luminal Androgen Receptor Triple-Negative Breast Cancer and Prostate Cancer

Investigators demonstrated that endoplasmic reticulum stress could decrease androgen receptor mRNA and protein levels via PERK/eIF2α/ATF4 signaling in luminal androgen receptor TNBC and prostate cancer.
[npj Breast Cancer]
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Overexpression of miR-375 Reverses the Effects of Dexamethasone on the Viability, Migration, Invasion and Apoptosis of Human Airway Epithelial Cells by Targeting DUSP6

The altered expression of microRNAs has been found in asthma. However, the detailed mechanisms responsible for the effects of miR‑375 on Dex‑induced airway epithelial cell dysfunction remain elusive. Researchers elucidated these mechanisms.
[International Journal of Molecular Medicine]
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Involvement of m6A Regulatory Factor IGF2BP1 in Malignant Transformation of Human Bronchial Epithelial Beas-2B Cells Induced by Tobacco Carcinogen NNK

Scientists performed colony formation assays, soft-agar assays, and tumor growth in nude mice to show that 100 mg/L Nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) facilitated the malignant transformation of human bronchial epithelial Beas-2B cells.
[Toxicology and Applied Pharmacology]
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CRISPR/Cas9 Editing of Directly Reprogrammed Myogenic Progenitors Restores Dystrophin Expression in a Mouse Model of Muscular Dystrophy

Scientists reported on reprogramming of fibroblasts from two Duchenne muscular dystrophy mouse models into induced myogenic progenitor cells by MyoD overexpression in concert with small molecule treatment.
[Stem Cell Reports]
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Prostate-Specific Membrane Antigen Modulates the Progression of Prostate Cancer by Regulating the Synthesis of Arginine and Proline and the Expression of Androgen Receptors and Fos Proto-Oncogenes

Scientists constructed prostate-specific membrane antigen (PSMA)-knockdown LNCaP and 22rv1 cell lines and performed metabonomic and transcriptomic analyses to determine the effects of PSMA on prostate cancer metabolism and transcription.
[Bioengineered]
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CircFBXW8 Acts an Oncogenic Role in the Malignant Progression of Non-Small Cell Lung Carcinoma by miR-370-3p-Dependent Regulation of TRIM44

The authors investigated the role of circular RNA F-box and WD repeat domain containing 8 (circFBXW8) in NSCLC progression and the underlying mechanism.
[Biochemical Genetics]
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Human Umbilical Cord Mesenchymal Stem Cells Improve the Necrosis and Osteocyte Apoptosis in Glucocorticoid-Induced Osteonecrosis of the Femoral Head Model through Reducing the Macrophage Polarization

The protein expression of AKT, mTOR, p-AKT and p-mTOR was detected using western blot assay. The results showed that human umbilical cord mesenchymal stem cells treatment prominently promoted the glucocorticoid-induced the decrease of the collagen level and the increase of TRAP positive cells.
[International Journal of Stem Cells]
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