protein expression

[Aging] Scientists investigated the effects of autophagy-inducing agent, Rapamycin, combined with the histone deacetylase inhibitor, Suberoylanilide Hydroxamic Acid, on the radiosensitivity of A549 and SK-MES-1 cells, and examined the combination effects on DNA damage repair, and determined the level of autophagy and acetylation in A549 cells.

[Inflammatory Bowel Diseases] Scientists evaluated the proapoptotic and antifibrotic efficacy of several classes of BH-3 mimetics in two in vitro fibrogenesis models. The candidate molecule, ABT-263, was advanced to a 3D human intestinal organoid model.

[Cell Death & Disease] Loss/gain-of-function method was applied to determine the roles of miR-361-5p and UBR5 in gliomas, as to cell viability, migration, invasion, colony formation ability, and apoptosis in vitro and tumorigenesis in vivo.

[Science Immunology] Scientists demonstrated that the loss of Pax5 by conditional mutagenesis in peripheral B lymphocytes led to the strong reduction of B-1a, marginal zone and germinal center B cells as well as plasma cells.

[Cell Death & Disease] In the presence of NOXA, BIM-deficient hepatocellular carcinoma cells could be in turn strongly sensitized for cell death induction by the combination of sorafenib with TNF-related apoptosis-inducing ligand .

[Science Translational Medicine] The authors reported the discovery of an intrinsic counter regulatory mechanism in colitis pathogenesis that may be targeted for inflammatory bowel disease treatment.